Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"GPR10"”.
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… coupled receptor in UL as the neuronspecific GPR10 (PRLHR), which activates the PI3K/AKT-mTOR pathway in UL cells upon stimulation by its ligand, PrRP (Prolactin-Releasing Peptide). Epigenetic silencing of GPR10 in non-neuronal cells is accomplished by the tumor-suppressor REST (Repressor …
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Mechanisms Involved in Human Thermogenesis
… mutations in G protein-coupled receptor 10 (GPR10), a G protein coupled receptor expressed in key brain areas associated with energy homeostasis. GPR10-mediated signalling in the dorsomedial hypothalamus is necessary for the thermogenic effects of leptin. We have undertaken a detailed …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… new mouse models: one with overexpressed human GPR10 and another with myometrial-specific Cre to ablate Rest, both showing promising similarities to human UL. These models offer potential for studying the pathogenesis and treatment of UL in vivo. However, there is still a need to develop new and …