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Showing 1 to 2 of 2 for “"GPI biosynthesis"”.
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Essential GPI Mannosyltransferases in Saccharomyces Cerevisiae and the Pathogenic Fungus Candida Albicans
… transfers a fourth mannose to a trimannosyl-GPI precursor in vivo. I determined that CaSMP3 is also an essential gene, as I was unable to recover homozygous null smp3 mutants from C. albicans, an obligate diploid. I created a conditional strain in which expression of CaSMP3 was controlled by …
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Synthetic strategies for potential trypanocides
… on the inhibition of glycophosphoinositol (GPI) anchor synthesis by inhibiting the Zn2+-dependent enzyme, GlcNAc-PI de-N-acetylase. Trypanosomes have a variable surface glycoprotein (VSG) coat, which allows them to evade the human immune system. The GPI anchor attaches the VSG to the cell …