Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"GPER"”.
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
<p>G-protein-coupled estrogen receptor 1 (GPER) is a G-protein-coupled receptor that induces non-genomic signaling in response to some nuclear estrogen receptor ligands. To date, the distribution and functional characterization of GPER within vertebrate organs have been restricted to juvenile and …
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The Non-genomic Signaling Pathways Mediated By G-protein Coupled Estrogen Receptor 1 (GPER) In Coronary Arteries
… the novel G protein-coupled estrogen receptor (GPER) which mediates estrogen action. The major purpose of my studies in this dissertation is to investigate the role of GPER in porcine coronary artery tone regulation. In a series of studies, we tested four hypotheses: 1) activation of GPER …
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Sex Specific Gene Expression Profiles In Fibrosis and Copd
… bound G protein-coupled estrogen receptor 1 (GPER), exhibited interesting expression patterns between disease and sex. ESR1 expression was stable across the control and mild COPD groups in both males and females, but expression increased with increased severity of IPF in females and decreased …
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The Influence of Estrogen Signaling on Male Reproduction in Medaka (Oryzias latipes)
… estrogen receptors (ESR1, ESR2a, ESR2b, and GPER), coupled with their ability for crosstalk and differential binding capability of selective estrogen receptor modulators (SERMS). Additionally, estrogen can signal through both classic genomic signaling and nongenomic signaling. Furthermore, …
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Estrogenic modulation of place and response learning via specific receptor-mediated mechanisms
… compounds that selectively target ERα, ERβ, or GPER. Rats then underwent maze training on a hippocampus-sensitive place task or dorsal striatum-sensitive response task. Our results reveal that treatment with estradiol, the isoflavone genistein, or selective agonists for ERα, ERβ, or GPER were …
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Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
… to GPCRs. First, we studied the activation of GPER-1 in pancreatic islets using two agonists G-1 and Estrogen (E2). Both G-1 and E2 displayed a similar response in mouse and human islets even in the presence of estrogen receptor blockers, ICI 182, 720 and EM652. G-1 and E2 potentiated insulin …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… (ERs) and G-protein-coupled estrogen receptor (GPER), plays important roles in humans and wildlife. Perturbing estrogen signaling may lead to deleterious health problems such as infertility, developmental defects, metabolic disorders, and certain types of cancers. A broad range of chemicals, …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
… expression of the alternative receptors ERβ and GPER was lower in HSPCs from responders compared with non-responders. Searching for alternative candidate receptors, aryl hydrocarbon receptor (AHR) was found to be highly expressed in responder HSPCs, and its transcriptional activity was activated …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the …