Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"GPCR Signaling"”.
-
Structural Studies of Integral Membrane Proteins Involved in GPCR Signaling and Sterol Homeostasis
… methyl-TROSY experiments on a wild-type human GPCR, and have significant value for future drug discovery efforts on this important class of membrane proteins. Second, I will discuss my endeavors to understand the important role of the protein Scap, which can both sense and respond to …
-
Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… role of the G protein-coupled receptor (GPCR) CB2 may result from pathway-selective signaling, contingent upon the diverse cancer-related signaling modulated by cannabinoid receptors. Nonetheless, the precise mechanism(s) by which CB2 regulates gene expression involved in cancer …
-
Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… evidence suggests that ARs are capable of signaling cross-talk with other G-protein coupled receptors (GPCRs) as well as other receptor families, including receptor tyrosine kinases (RTKs). While the ARs have been implicated at numerous stages of heart failure, the adrenergic signaling …
-
IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
Chronic psychostimulant exposure alters the signaling of G-protein coupled receptors (GPCRs), which is associated with drug relapse. Although the molecular mechanisms remain unknown, scant evidence suggests a potential role of membrane lipids especially cholesterol in regulation of …
-
RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
… of D2R trafficking by the regulator of G protein signaling, RGS2. Though RGS2 is most commonly associated with termination of GPCR signaling through accelerated GTPase activity, this study reveals a novel role of RGS2 knockdown in the modulation of quinpirole, a D2/D3 agonist, stimulated D2R …
-
Structural Basis of GPCR-Transducer Signaling
<p>G protein-coupled receptors (GPCRs) are a class of ubiquitous cell-surface receptors involved in the regulation of virtually every physiological processes. GPCRs typically signal through either G proteins or beta-arrestins (βarrs), each of which activate distinct cellular pathways that leads to …
-
Application of Genetically-Encoded Photoactivatable Crosslinkers to Map Ligand-Binding Sites on G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce biological signals. Although GPCRs represent the largest class of targets for therapeutic agents, ligand-binding sites have been precisely defined for only a small percentage of the …
-
Transcriptome and Functional Analysis of Carotid Body Glomus Cells
… on the underlying molecular machinery and signaling pathway in CB glomus cells is still limited. </p><p>To overcome these limitations, in chapter 1, I demonstrated the first transcriptome profile of CB glomus cells using single cell sequencing technology, which allowed us to uncover a set …
-
Alternative rownstream roles for Ste2p and an α-arrestin in sacccharomyces cerevisiae mating
… yeast pheromone G-protein Coupled Receptors (GPCR) those are involved in the signaling of mating responses that lead to cell fusion. Their signaling–associated interactions with G-protein/MAPK signal transduction machinery are well established, homologous to those in mammalian systems, and …
-
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all prescribed drugs. Cells utilize these receptors to transduce extracellular stimuli …
-
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all prescribed drugs. Cells utilize these receptors to transduce extracellular stimuli …
-
Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… type 2 diabetics. G-protein coupled receptors (GPCR) represent the largest non-antibiotic drug targets and several family members are expressed in beta cells. Regulators of G-protein Signaling (RGS) proteins are feedback regulators of GPCRs. Their expression can be induced by GPCR or cross-talk …
-
Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… is controlled via a complex network of cell signaling mechanisms. Among the broad network of receptors and signaling molecules regulating blood vessel reactivity, members of the G protein-coupled receptor (GPCR) family are known to play a central role. GPCR activity represents a delicate, but …
-
Development of Novel Chemical Biology Tools for Probing Structure-Function Relationships in G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) constitute a large family of transmembrane receptors that transduce extracellular signals into intracellular biochemical responses. Understanding with chemical precision how GPCRs function in cellular membranes is an active area of biological research, but …