Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 211 for “"GPCR"”.
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Studies in GPCR and Chromosomal Control
This dissertation is divided into two distinct parts. The first chapter is focused on regulation of serotonin receptors and signaling to address drug addiction, while the second chapter is focused on a novel synthetic approach towards a small molecule inhibitor of Ewing’s sarcoma. Drug addiction is …
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Structural Basis of GPCR-Transducer Signaling
<p>G protein-coupled receptors (GPCRs) are a class of ubiquitous cell-surface receptors involved in the regulation of virtually every physiological processes. GPCRs typically signal through either G proteins or beta-arrestins (βarrs), each of which activate distinct cellular pathways that leads to …
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Single-molecule dynamics of GPCR signal transducers
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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GPCR to Channel Communication in a Membrane Signaling Pathway
<p>G-protein-coupled receptors (GPCRs) regulate a variety of downstream effector proteins, making them essential for many physiological processes. For example, in the heart, the activation of beta-adrenergic receptors (βARs) and the stimulatory G protein (Gαs) leads to the opening of downstream …
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Structure and activation of the class D GPCR dimer Ste2
G protein-coupled receptors (GPCRs) are eukaryotic membrane proteins that perform a broad range of cell signalling functions and are targets for approximately one-third of all FDA- approved drugs. GPCRs are divided phylogenetically into six classes, A-F. Over 700 structures of mammalian GPCRs …
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
… including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, and therefore play important roles in regulating physiological processes including innate immunity, glucose homeostasis, …
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Investigating the immunosuppressive functions of the GPCR adapter protein Norbin
… and signalling of G protein-coupled receptors (GPCRs). Norbin was originally expected to be exclusively neuronal. However, previous PhD students in our laboratory found that Norbin is also expressed in myeloid cells and made mice with myeloid Norbin deficiency (Ncdn<sup>Δmye</sup>) to …
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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel
… different G protein-coupled receptors (GPCRs), which in turn activate ion channels that modify the electrical properties of cardiac pacemaker cells. Sympathetic stimulation accelerates heart rate through activation of beta-adrenergic receptors (βARs), which open excitatory ion channels …
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Structural Studies of Integral Membrane Proteins Involved in GPCR Signaling and Sterol Homeostasis
… methyl-TROSY experiments on a wild-type human GPCR, and have significant value for future drug discovery efforts on this important class of membrane proteins. Second, I will discuss my endeavors to understand the important role of the protein Scap, which can both sense and respond to …
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Identifying a Glucocorticoid-activated GPCR that Rapidly and Non-Genomically Increases cAMP Levels in Mammalian Cells
… effect is mediated by a G<sub>s</sub>-coupled GPCR and that GC-induced non-genomic actions contribute to later genomic actions. To carry out the study, I will focus on the following aims a). Demonstrate that GC rapidly stimulate cAMP levels b). Test the involvement of G𝛼<sub>s</sub> in the …
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Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
… receptor (A₂AR), a G protein‑coupled receptor (GPCR) highly expressed in TNBC, contributes to immunosuppression and tumor progression. Caffeine, a consumed A₂AR antagonist, has been reported to modulate cancer-associated signaling pathways, although its non-canonical mechanisms remain poorly …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… role of the G protein-coupled receptor (GPCR) CB2 may result from pathway-selective signaling, contingent upon the diverse cancer-related signaling modulated by cannabinoid receptors. Nonetheless, the precise mechanism(s) by which CB2 regulates gene expression involved in cancer …
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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… of many aspects of G protein-coupled receptor (GPCR) biology and pharmacology. The RAMP family was discovered more than two decades ago and GPCR-RAMP interactions and their functional consequences on receptor trafficking and ligand selectivity have been documented for several GPCRs, mostly …
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Modelling fitness and stability of G protein-coupled receptor variants
G protein-coupled receptors (GPCRs) are the molecular targets of more than a third of approved drugs1 used in a wide variety of diseases2. Protein-altering genetic variants have complex effects on the biophysical and functional properties of GPCRs. Understanding the biophysical and functional …
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Identification of Previously Unknown Interactions Between G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
<p>G protein-coupled receptors (GPCRs) are known to interact with several other classes of integral membrane proteins. However, the extent of these interactions and their role in regulating GPCR-mediated transmembrane signaling is not well understood. For example, receptor activity-modifying …
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Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
… migration and ROS generation in response to GPCR activation—functions traditionally attributed to its Rac-GEF activity. Additionally, previous findings from our laboratory demonstrated a GEF-independent role for P-Rex1 in GPCR trafficking. This thesis investigates Rac-GEF-independent …
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Untersuchungen zum Mechanismus der liganden-vermittelten Transaktivierung des epidermalen Wachstumsfaktor Rezeptors
… von G-Protein gekoppelten Rezeptoren (GPCR) tyrosinphosphoryliert, sog. Transaktivierung, und trägt zur mitogenen Signalübertragung verschiedenster GPCR in normalen als auch in humanen Krebszellen bei. Im Rahmen dieser Arbeit konnten Zink-abhängige Metalloproteasen als auch der EGFR …
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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… members of the G protein-coupled receptor (GPCR) family are known to play a central role. GPCR activity represents a delicate, but coordinated balance between molecular mechanisms governing receptor signaling, desensitization, and re-sensitization. GPCR kinase 2 (GRK2) modulates multiple …
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Alternative rownstream roles for Ste2p and an α-arrestin in sacccharomyces cerevisiae mating
… yeast pheromone G-protein Coupled Receptors (GPCR) those are involved in the signaling of mating responses that lead to cell fusion. Their signaling–associated interactions with G-protein/MAPK signal transduction machinery are well established, homologous to those in mammalian systems, and …
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