Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"GOAT inhibition"”.
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Formation of Pyrroloindolines and Alkylation of N-heterocycles With Trichloroacetimidates and Synthesis of Quinoline Based Small Molecule Inhibitors of Ghrelin O-acyltransferase (goat)
… octanoylated by ghrelin O-acyltransferase (GOAT). Inhibition of GOAT offers an enzymatic target to control appetite, presenting a potential method for the development of small-molecule therapeutics to treat obesity and diabetes. A heterocyclic lead compound has been identified that shows …
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Ghrelin Processing and Maturation: Developing a Molecular-Level Framework for Hormone Activation and Biological Function
… states, ghrelin signaling is a prime target for inhibition and inhibitor development. Biochemical and structural studies of the enzyme responsible for ghrelin octanoylation, ghrelin O-acyltransferase (GOAT), have identified features required for recognition of ghrelin by GOAT. A majority of these …