Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"GNA13"”.
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Integrative Genomics Reveals a Role for GNA13 in Lymphomagenesis
… mutations in the G alpha binding protein GNA13 and associated focal adhesion proteins. I aim to describe how loss-of-function mutations in GNA13 can be oncogenic in the context of germinal center B cell biology. Using in vitro techniques including liquid chromatography-mass spectrometry …
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Revealing the role of Gα13 in germinal centre lymphomas
… of many of the recurrently mutated genes. *GNA13* encodes Gα13, the alpha subunit which forms part of the heterotrimeric G protein complex involved in signal transduction pathways. The Gα13 pathway regulates the growth and confinement of GC B cells and *GNA13* is recurrently inactivated in …
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Elucidating oncogenic mechanisms in human B cell malignancies
… B cell lymphomas. These experiments identified GNA13 as an unexpectedly potent tumour suppressor in human GC B cells and provided new understanding to its mechanism of action. These findings provide novel understanding of the complexity of oncogenic mechanisms in human B cell malignancies.
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… and non-targeted genes (*TET2*, *CD274*, *FAS*, *GNA13*). Subset analysis according to chromosome translocation revealed that *BCL2* translocation positive FLs were enriched for *CREBBP*, *KMT2D*, *EZH2*, but lacked *TET2*, *CD274* and *IGLL5* mutations, while *BCL2* translocation negative FL …