Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"GM3"”.
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Identification and characterization of an enterocyte receptor for group A porcine rotavirus
… chromatographic mobility between that of GM2 and GM3. Inhibition of blocking activity by treatment of GMX with neuraminidase and ceramide glycanase, but not by treatment with protease or heat (100$\sp\circ$C) supported the identification of GMX as a ganglioside. Further purification of GMX by HPLC …
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… Immunofluorescence was used to stain for GM1 and GM3 species and ESI-MS was used to quantify the ganglioside species expressed within these injured neurons, which were compared to expression profiles of healthy neurons. Neurons were also pretreated with GM1 24 h before glutamate exposure to assess …
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Frameworks for estimating virtual water flows among U.S. states
… the country. For the year 2008, states used 196 Gm3 of water to produce agricultural commodities (crops and livestock) that were exported for consumption in other states. This total virtual water export volume is equivalent to 35 percent of total water withdrawals for all sectors in the U.S., or …
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Characterization of Gangliosides and Fatty Acids in Extracellular Vesicles from Human Milk
… milk. In contrast, 13/15 molecular species of GM3 and GD3 assessed were not positively correlated between human milk EVs and human milk. Total saturated species of GM3 are enriched 2-fold in human milk. GM3 d40:1, GM3 d34:1, and GD3 d36:1 are significantly enriched in human milk EVs. 18:2 and …
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New Methodology for Alpha-Sialyl Glycoside Synthesis
… of the trisaccharide portion of ganglioside GM3 are also discussed.
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… One set of experiments showed that ganglioside GM3 induces dimerization of α5β1 integrins in a CHOL-free lipid bilayer, while addition of CHOL suppresses such a dimerization process. Furthermore, GM3 was found to recruit α5β1 integrin into CHOL-enriched domains, illustrating the potential …
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IS B4GALT5 DEFICIENCY A NEW CONGENITAL DISORDER OF GLYCOSYLATION?
… substrates in vitro and to restore LacCer and GM3 ganglioside expression upon transfection in double KO HEK-293T cells. In silico studies of mutated proteins revealed pronounced conformational instability compared to the wildtype, affecting both protein backbone and UDP-Gal binding. ΔStability …
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Molecular therapy for mucopolysaccharidosis Type I
… (Chapter 2). However, pathogenic accumulation of GM3 ganglioside, not normally expressed in the brain, remained present in treated animals. This highlights the necessity to achieve more efficient delivery of IDUA to the central nervous system in order to normalize brain biochemistry. Thus, I …
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Glycolipids in mouse F9 teratocarcinoma cells: some changes associated with retinoic acid-induced differentiation
… (Galβ1,3Ga1NAcβ1,4[NeuAcα2,3] Galβ1,4Glc) and GM3 (NeuAcα2,3Galβ1,4Glc) in RAlF9 cells relative to controls. These changes were accompanied by a decrease in the synthesis of sialyltetrasaccharide a (NeuAcα2,3Galβ1 ,3GlcNAcβ1 ,3Galβ1,4Glc) and sialylparagloboside (NeuAcα2,3Galβ1 ,4GlcNAβ1 …
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Structural analysis of glycolipid-derived oligosaccharides from metabolically radiolabelled colorectal carcinoma SW1116 cells
… as previously reported by Magnani et al. [183]. GM3 (NeuAcα2-3Galβ1-4Glc-Cer) (0.42% of radioactivity recovered in glycolipids), sialyltetraosylceramide a (NeuAcα2-3Galβ1-3GlcNAcβ1-3Galβ1-4Glc-Cer) (0.46% of radioactivity in glycolipids), sialyltetraosylceramide b …
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LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… to sphingolipid metabolism, specially the GM3 synthase and sialidase. Additionally, the administration of GM1, previously noted for improving the rescue of F508del-CFTR with Orkambi (consisting of the corrector VX-809 and potentiator VX-770), has also shown effectiveness with Kaftrio, …
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Isolierung und strukturelle Charakterisierung von E-Selektin-bindenden Gangliosiden aus humanen Granulozyten
… enthielt hauptsächlich die Ganglioside GM3, IV3Neu5Ac-nLc4,IV6Neu5Ac-nLc4 und VI3Neu5Ac-nLc6. Die weiteren Fraktionen bestanden aus komplexen Gemischen von fukosylierten und nicht-fukosylierten Gangliosiden mit Poly-N-Acetyllaktosaminylketten, die als langkettige Strukturen bezeichnet …
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El papel de los lípidos en la estructura y función del receptor de acetilcolina nicotínico
… niveles celulares de SM y gangliósidos como el GM3 a valores menores del 1%. Con este modelo, determinamos que no existen diferencias en los parámetros electrofisiológicos y en las propiedades farmacológicas del receptor, y caracterizamos la participación activa de la SM en los mecanismos que …
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The role of heterozygous lysosomal storage disorder alleles as risk factors for dementia
… by Hexb), or related gangliosides, GM1 or GM3. Surprisingly, heterozygosity of Hexb resulted in less amyloid beta plaques in the orbital cortex and hippocampus of 46-week-old AppNL-G-F/NL-G-F mice and less Aβ42 in the hippocampus. In summary, Hexb heterozygosity in AppNL-G-F/NL-G-F mice did …
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Abschätzung der mikrobiellen Diversität in anoxisch sauren Sedimenten von Braunkohle-Restseen unter Berücksichtigung des Eisenschwefelkreislaufs
… der Geobacteriaceae gefunden. Mit dem Primer-Set GM3/Geo825R für Geobacter konnte ein positives Signal in Zone III bei einer Verdünnugsstufe von 10-1 erhalten werden. In Zone I und Zone II lag die höchste positive Verdünnungsstufe bei 100. Mit dem Primer-Set Gb564/Gb1290 ergab sich ein leicht …