Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"GM2A"”.
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The Role of GM2 Activator Protein in Breast Cancer Metastasis and the EGFR Signaling Pathway
… disease. The role of GM2 Activator Protein (GM2A), an important transport molecule in ganglioside breakdown, however, has not been thoroughly investigated. In this study, we investigated the role of GM2A protein in metastatic characteristics such as cell proliferation, cell migration, and …
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Correction of AB Variant GM2 Gangliosidoses Using AAV9 Viral Vector Gene Therapy in a Mouse Model
… action of three gene products, HEXA, HEXB, and GM2A. A defect in any one of these genes can result in a deficiency of Hexosaminidase A (HexA) enzyme activity, which then cannot breakdown GM2 gangliosides. The rarest form of these diseases, the AB-variant (AB- GM2), is characterized by a mutation …