Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"GM2 activator"”.
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The Role of GM2 Activator Protein in Breast Cancer Metastasis and the EGFR Signaling Pathway
… progression of metastatic disease. The role of GM2 Activator Protein (GM2A), an important transport molecule in ganglioside breakdown, however, has not been thoroughly investigated. In this study, we investigated the role of GM2A protein in metastatic characteristics such as cell proliferation, …
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Correction of AB Variant GM2 Gangliosidoses Using AAV9 Viral Vector Gene Therapy in a Mouse Model
GM2 Gangliosidoses are a group of neurodegenerative diseases affecting the brain. In humans, these diseases are characterized by rapid neurological deterioration and death before 4-years of age. GM2 gangliosides are normally degraded in a cell’s lysosomes through the action of three gene products, …