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Showing 1 to 20 of 30 for “"GM1"”.
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Molecular characterization of ovine GM1 gangliosidosis
Ovine GM1-gangliosidosis is an autosomal recessive lysosomal storage disorder. Affected lambs are born relatively normal, however at approximately four months of age they begin exhibiting severe neurological symptoms. Pathology progresses rapidly in affected lambs ultimately resulting in death by …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
<p>Background. GM1-ganglisidosis is a rare neurodegenerative lysosomal storage disease caused by the deficiency of the lysosomal enzyme β-GAL, resulting in the accumulation of its target substrate GM1. GM1, a glycosphingolipid found primarily in the PM of neurons, is known to modulate Ca2+ flux …
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Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain
… from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in …
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… 24 h. Immunofluorescence was used to stain for GM1 and GM3 species and ESI-MS was used to quantify the ganglioside species expressed within these injured neurons, which were compared to expression profiles of healthy neurons. Neurons were also pretreated with GM1 24 h before glutamate exposure …
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A New Class of Antibiotic That Prevents Drug Tolerance, Persistence, and Resistance By Controlling Emergence of Phenotypes.
… Glycolipid, ganglio-N-tetraosylceramide (asialo-GM1), on the mammalian cells are known to be recognized by type IV pili of Pseudomonas aeruginosa. In this work, we show that asialo-GM1 can also be recognized by Lectin A (LecA), another adhesin protein of the P. aeruginosa, by a fluorescent …
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A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain Barré Syndrome
… prevalent (20-30%) immunoglobulin in GBS is anti-GM1 (20-30%), which also binds to the LPS of the PEN O:19 Campylobacter jejuni serotype. This is the most common infectious agent associated with GBS and emphasizes the importance of infection and anti-ganglioside antibodies in disease development. …
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… between GD3 and other<br/> gangliosides such as GM1 in biological systems and thereby its impact on NK<br/> cell biology. B16 (78) cell line was genetically modified to over-express both<br/> GD3 and GM1.<br/> This model system was then analysed using Siglec-7-Fc precomplexes for the<br/> …
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LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… known as lipid rafts. In fact, the ganglioside GM1 is an important bioactive sphingolipid that has been reported to play a crucial role in the control of several plasma membrane (PM) proteins and its correlation with CFTR prompts speculations about its possible role in the CFTR interactome. …
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Development of a high-throughput shotgun-mass spectrometry method for qualitative and quantitative analysis of major mammalian brain gangliosides
… the major mammalian brain ganglioside classes: GM1, GD1, GT1 and GQ1. As a starting point for the method to be developed, a modified ganglioside extraction method from Svennerholm and Ladisch was used (Svennerholm and Fredman, 1980; Ladisch and Gillard, 1985). The efficiencies and the impact of …
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Studies of Carbohydrate-Binding Proteins from Enterotoxigenic Escherichia coli
… are highly similar, and all of them bind to the GM1 ganglioside. pLTB also binds neolacto sequences and hLTB blood group A type 2 sequences. A B-subunit (CFXB), with 73% sequence identity to CTB, is found in Citrobacter freundii and some ETEC strains. Binding studies showed that CFXB binds with …
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The Development and Characterization of Scaffolded Vesicles as a Model Membrane
… (DPhPS), and a DMPC, cholesterol, ganglioside GM1 membrane in a 40:30:30 DMPC:cholesterol:GM1 molar ratio. Each of these scaffolded vesicles were characterized using ATR-IR spectroscopy, fluorescence microscopy, fluorescence quenching, fluorescence recovery after photobleaching (FRAP), and …
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"Funcionalidad de los microdominios de membrana en la señalización durante la maduración meiótica de anfibios"
… enriquecida en colesterol y en el gangliósido GM1 y presenta un nivel importante de esfingomielina. Las membranas livianas muestran un enriquecimiento en una caveolina de 21 kDa indicando la existencia de estructuras tipo-caveolares en el ovocito de Bufo arenarum. Además, están asociadas …
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Expression Of Cholera Toxin B Subunit-rotavirus Nsp4 Enterotoxin Fusion Protein In Transgenic Chloroplasts
… retained the binding affinity to the enterocytes GM1 ganglioside receptor. Expression levels of CTB-NSP4 protein was quantified by GM1 ganglioside binding ELISA assay; mature leaves expressed CTB-NSP4 fusion protein to upto 2.45 % in total soluble protein, 100-400 fold higher than nuclear …
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
… channel are either reduced or increased by anti-GM1 and anti-GQ1b antibodies respectively. These interactions between voltage-gated calcium channel and anti-ganglioside antibodies are dependent on the auxiliary a2d subunit of calcium channel.
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Existence and Stability of Solitary Waves for NLS with Defects
… of Germain, Harrop-Griffiths and Marzuola, \cite{GM1}, who have previously established orbital stability for some specific waves, in the range $p<8$.
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Potential Mechanisms Explaining the Antitumor Effect of Total-Body Irradiation
… experimentation substantiated that asialo GM1+ and NK1.1+ cells operated in tumor surveillance in the LLC tumor model and were involved in mediating the antitumor effect of TBI. The findings also demonstrated that radiation exposure can activate NK cells, inducing increased population …
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Early Diagnosis of Alzheimer's Disease and Studying Binding to Opioid Receptors using Whispering Gallery Mode Microtoroid Biosensors
… with an artificial lipid membrane doped with GM1-ganglioside receptors to study interactions with the Cholera Toxin subunit B, which is responsible for Cholera disease. In the second study, the surface of microtoroids were functionalized with an artificial lipid membrane embedded with kappa …
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Hydrodynamics and Diffusion of Membrane Proteins to Engineer Chemical Reactions in Synthetic Biomembrane Platforms
… Progress in synthesizing the ganglioside GM1 via sequential enzymatic addition of two sugar monomers is then described. In conclusion, additional steps needed to achieve the development of a microfluidic SLB platform to carry out sequential enzymatic reactions are discussed.
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