Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"GLUT2"”.
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… (SGLT1) and glucose transporter 2 (GLUT2). GLUT2 is a high-capacity, facilitative intestinal monosaccharide transporter that is upregulated by the short-chain fatty acids (SCFA) derived from the intestinal microbiota during fermentation. The objective was to identify the impact of …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… sodium-independent glucose transporter, GLUT2, was increased to enteral levels by all GLP-2 doses. Furthermore, the low GLP-2 dose increased brush border membrane (BBM) protein abundance of GLUT2. This increase corresponded with an increase in glucose uptake, indicating that GLP-2 may be …
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Mechanism of Insulin Release From Islets of Langerhans in a Rat Model of Normal Infants and Infants of Diabetic Mothers
… release, and protein expression of GLUT1, GLUT2, and glucokinase by immunocytochemistry in the isolated islet and Western blot on the whole pancreas. The IDM had significantly lower mean body weights at all ages studied (p $<$ 0.01, n $\ge$ 34); significantly higher mean plasma glucose …
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Dietary and Developmental Regulation of Nutrient Transporter Gene Expression in the Small Intestine of Two Lines of Broilers
… sugar transporters (SGLT1, SGLT5, GLUT5, and GLUT2), and a digestive enzyme, APN. For PepT1, Line B had greater quantities of mRNA compared with Line A (P = 0.001), suggesting a greater capacity for absorption of AA as peptides. Levels of PepT1 mRNA were greatest in the duodenum (P < 0.05), …
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Caractérisation du rôle du récepteur P2X7 dans le transport du glucose par les cellules épithéliales intestinales et le contrôle de la glycémie et du métabolisme
… P2X7, la translocation à la membrane de GLUT2, le transporteur facilité du glucose, du fructose et du galactose dans l’intestin, était diminuée. Cette diminution d’expression s’accompagne d’une diminution d’absorption dans les cellules IEC-6 et d’une diminution du transport …
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Small Intestinal Transporters in Two Species of Galliformes: Male and Female Turkey (Meleagris gallopavo) and Chicken (Gallus gallus)
… LAT1, y+LAT2), and sugar transporter expression (GLUT2, GLUT5, SGLT1) in the small intestine of male and female turkeys. Small intestine samples were collected during embryonic development (E21, E24) and DOH. In a separate experiment during post-hatch development (DOH, D7, D14, D21, D28). APN, …
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Expression of Digestive Enzymes and Nutrient Transporters in the Intestine of Eimeria-challenged Chickens
… LAT1 and y+LAT1/2, sugar transporters: GLUT1, GLUT2, GLUT5 and SGLT1, mineral transporter: ZNT1 and an immune factor: LEAP2 in the duodenum, jejunum, ileum and ceca of Eimeria-challenged layers and broilers. Comparisons were made between E. acervulina-challenged layers and broilers and E. …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
… the expression of glucose transporter genes (GLUT2 and SGLT1) and induced an acute (15 min) inhibitory effect on enterocytic glucose uptake. 2) Chronic treatment (16 h) with berry extract modulated the expression of genes that regulate iron uptake (down-regulation of DMT1, DCYTB and HFE; …
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Production, characterization and evaluation of anti-diabetes peptides from proteins of improved common bean (Phaseolus vulgaris L.) cultivars using bioinformatic tools, enzymatic systems, and in vitro and in vivo models
… intestinal glucose transporters SGLT1 and GLUT2. Besides, using Caco-2 cells monolayer insert we observed that protein fractions reduce glucose absorption by 6.5 and 24.5 after 30 min and 24 h, respectively. It could be due to protein fractions were also able to decrease protein expression …
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Chickens from lines artificially selected for juvenile low and high body weight differ in glucose homeostasis and pancreas physiology
… PPI; preproglucagon, PPG; glucose transporter 2, GLUT2; and pancreatic duodenal homeobox 1, Pdx1) in LWS, than HWS chickens. Histological analysis of pancreas revealed that HWS chickens have larger pancreatic islets, less pancreatic islet mass, and more pancreatic inflammation than LWS chickens, …
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Somatic cell gene therapy for diabetes mellitus: engineering a surrogate B-cell
… the human preproinsulin gene (hppI-1) and the GLUT2 gene for the glucose transporter isoform 2. Insulin secretion was responsive to changes in the glucose concentration up to about 50μM. Further studies to up-rate this glucose sensitivity into the mM range will require manipulation of the …
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Effects of Incubation Temperature and Transportation Stress on Yolk Utilization, Small Intestine Development, and Post-Hatch Performance of High-Yield Broiler Chicks
… and relative nutrient transporter (SGLT1, GLUT2, GLUT5, EAAT3, and PepT1) gene expression. The objective of the second study was to evaluate the effects of embryonic incubation, simulating a multi-stage incubation system, and post-hatch transportation temperatures on post-hatch performance, …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… receptor (IR-A) and glucose transporter type 2 (GLUT2), affecting the -cell ability to secrete insulin. Concurrently, we also focused on muscle tissue, a major regulator of systemic glucose homeostasis. Notably, glucose uptake by muscle requires the secretion of insulin. In muscle cells, we …
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Studies of TNF- α-induced -GSIS Inhibition in INS-1 β-cell
… of TNF-α for 24h, expression of insulin, GLUT2 and GK did not affect. ATP production didn't, neither. This indicates that insulin biosynthesis, glucose uptake and oxidative metabolism have no effect by TNF-α treatment. Glucose stimulated Ca(2+)+ influx and Ca(2+)+ oscillation was decreased …
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Fettsucht mit erhöhter D-Glukose-Absorption im Dünndarm durch Inaktivierung des Regulatorproteins RS1 bei Mäusen
… Konzentration des passiven Glukosetransporters GLUT2 in der basolateralen Membran nicht verändert war. Die Zunahme der SGLT1-Proteinmenge war posttranskriptional bedingt. Bei der RS1-knock-out Maus wirkt sich der in Oozyten beobachtete Effekt an der Plasmamembran aus, während der an konfluenten …
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The effects of metformin on the gastrointestinal tract
… whilst decreasing the expression of Slc2a2 (GLUT2) and Slc5a1 (SGLT1). This was replicated in the distal small intestine of HFD-fed mice treated with metformin. Metformin also increased GLUT-transporter mediated glucose uptake in cultures. These mechanisms may potentially be mediated by AMPK …
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Reducing crude protein levels in diets fed to young pigs to optimize growth performance and intestinal health
… trefoil factor-2, trefoil factor-3, mucin-2, GLUT2, and GLUT5 were all decreased (P < 0.05) when pigs were fed the 16% CP diet, whereas expression of transforming growth factor-β was increased when the 16% CP diet was fed instead of the 22 or 19% diets. In conclusion, low CP diets for weanling …
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Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
… studies several known (insulin, glucagon, Glut2, PC2) but also novel genes were shown to be differentially expressed in MafB and MafA/MafB compound mutant embryos. Gene ontology analysis revealed that the differentially expressed genes were mainly associated with mature β-cell function. Our …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… fasted state and increased the glucose-sensing Glut2 protein levels in the liver, supporting that α-LA may promote the hepatic glucose export during fasting in order to provide glucidic reserves to the other organs as physiologically occurs. After glucose injection, AIP mice receiving α-LA …