Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"GLUT1"”.
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Role of glucose transporter 1 during pregnancy
… shown that Hif2α regulates Glucose transporter1 (GLUT1). GLUT1 is the dominant glucose transporter in the uterus and has been linked to human infertility. Based on these points, we chose to investigate the role of GLUT1 in pregnancy by deleting GLUT1 from the uterus using two transgenic models. …
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IMPACT OF KETOGENIC DIET TREATMENT IN GLUT1 DEFICIENCY SYNDROME: DISCOVERY OF MOLECULAR MECHANISMS RESPONSIBLE FOR PHENOTYPE CHANGES IN BOTH PEDIATRIC AND ADULT PATIENTS
La sindrome da deficit di GLUT1 (GLUT1-DS) è una rara condizione neuro-metabolica, causata da mutazioni nel gene SLC2A1, che codifica per il trasportatore del glucosio, GLUT1. La carenza di GLUT1 riduce significativamente l’apporto di glucosio al cervello, compromettendone il funzionamento e …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic and hypoxic environments utilizing an <em>in-vitro</em> GBM model. The data accumulated in this …
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Anpassung der lokalen zerebralen Glukosetransporterdichten an Veränderungen der lokalen Glukoseutilisation und ihre Auswirkungen auf die lokalen Glukosetransportraten im Rattenhirn
… sieben Mitglieder dieser Genfamilie gefunden und GLUT1 bis GLUT7 benannt. Im Gehirn wurde hauptsächlich das Glukosetransportmolekül GLUT1 in Endothelzellen der Blut-Hirn-Schranke und perivaskulären Astrozyten gefunden, während GLUT3 auf Neuronen lokalisiert ist. Ob lokale Veränderungen der Dichten …
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Regulation of glucose transporters in sheep placenta
… Although the presence of glucose transporter-1 (GLUT1) and GLUT3 has been demonstrated in mammalian placenta, the factors regulating these genes remain unclear. Therefore, the overall aim of these studies was to clone ovine GLUT1 (oGLUT1) and oGLUT3 cDNAs, and to use these to investigate gene …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… expressions of aerobic glycolysis related genes (GLUT1, PGK1 and PDK1), and the rate of glucose uptake in those cells. HIF 1α was highly expressed in SNU216, and the responsiveness of SNU216 to 5-FU was lower than it of MKN45. The expressions of glucose transporter 1(GLUT1), …
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Characterization of GSDMD as a Positive Regulator of Breast Cancer Cell Proliferation and Mammary Tumorigenesis
… between GSDMD and glucose transporter 1 (GLUT1), a protein pivotal in glucose uptake and metabolism. Here, we revealed that GSDMD and GLUT1’s interaction synergistically enhanced glucose transport activity and cell proliferation in BC cells. Future elucidation of these findings using in …
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Positioning Microtissues on the Differentiation Continuum Reveals their Utility for Studying Skeletal Myopathies and Metabolic Disease
… GLUT4 and elevated levels of insulin-independent GLUT1, limiting their relevance for modeling insulin resistance. Human skeletal muscle microtissues, differentiated under uniaxial tension across two microposts, exhibit greater insulin responsiveness than 2D myotubes and are amenable to contractile …
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Investigation of Tanycytes and Orexin Neurons in the KCNA1-Null Mouse Model of Epilepsy
… changes in the expression of tanycytic proteins GLUT1, GFAP, and DCX and evaluated the impact of a 2-week KD treatment. Compared to controls, SRS mice showed elevated GFAP levels, decreased GLUT1 levels, and no change in DCX levels. The KD treatment did not significantly alter these outcomes, …
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Mechanism of Insulin Release From Islets of Langerhans in a Rat Model of Normal Infants and Infants of Diabetic Mothers
… insulin release, and protein expression of GLUT1, GLUT2, and glucokinase by immunocytochemistry in the isolated islet and Western blot on the whole pancreas. The IDM had significantly lower mean body weights at all ages studied (p $<$ 0.01, n $\ge$ 34); significantly higher mean plasma …
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EXPANSION OF CLINICAL PHENOTYPE AND USE OF KETOGENIC DIET IN RARE GENETIC CONDITIONS: GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME AND SCN8A-RELATED DISORDERS
… Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS) and conditions associated with pathogenic variants in the SCN8A gene. The aim was to expand the understanding of the clinical phenotype and disease progression, as well as to evaluate the efficacy of the ketogenic diet (KD) as a treatment. …
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The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis
… is essential for EGF-induced Akt activation, Glut1 expression, and glucose uptake. AMPK is also required for various stresses induced Akt activation and promote cell survival, including hypoxia and glucose deprivation. In addition, we found glucose deprivation-induced VEGF expression and …
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
… and also reassesses the localization of Glut1, a third protein formerly believed to reside in the outer segment. All three experimental lines relied on in vivo expression of novel protein constructs in vertebrate rods using several gene delivery strategies: conventional transgenics, …
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Developing and utilizing a robust mass spectrometry-based approach to study glucose metabolism and transport in the lens
… Using spatial proteomics, I discovered that GLUT1 is the predominant isoform expressed in the lens fibres, and GLUT3 is predominantly expressed in the lens epithelium. The location of GLUT1 was further confirmed using immunohistochemistry. Subsequently, MALDI-IMS demonstrated that, once …
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Finding lncRNAs in bone marrow and fetal liver erythroid progenitor cells in mice
… the differentially expressed genes, most notably Glut1, and that there is no clear difference in chromatin markings near transcription start sites of differentially expressed genes. Further work will analyze enriched transcription factor motifs inside DNase-I footprints generated in this work to …
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Expression of Digestive Enzymes and Nutrient Transporters in the Intestine of Eimeria-challenged Chickens
… EAAT3, LAT1 and y+LAT1/2, sugar transporters: GLUT1, GLUT2, GLUT5 and SGLT1, mineral transporter: ZNT1 and an immune factor: LEAP2 in the duodenum, jejunum, ileum and ceca of Eimeria-challenged layers and broilers. Comparisons were made between E. acervulina-challenged layers and broilers and …
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Investigating the role of estrogen deprivation and diet-induced insulin resistance on markers of amyloid-β production and degradation in the brain
… led to exacerbated decreases in pGSK-3β /GSK, GLUT1, and Homer-1 (a postsynaptic marker) in the hippocampus, and GLUT3 in the prefrontal cortex. Data from this study provide evidence of a synergistic effect of systemic insulin resistance and estrogen loss in decreasing brain markers of Aβ …
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Investigating the role of the UDP-galactose transporter SLC35A2 in the regulation of HIF signalling
… and elevated expression of HIF-α target genes (*GLUT1*, *VEGF*). Using global RNAseq analysis of SLC35A2 KO and WT sHeLa cells, I found that SLC35A2 loss was associated with highly upregulated expression of a range of genes. Further exploration of the observed glycosylation defect in Slc35a2 …
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Hypoxiemarker im equinen Endometrium im klinisch-pathomorphologischen Kontext
… factor 1α (HIF-1α), Glucosetransporter 1 (GLUT1), vascular endothelial growth factor A (VEGF A) und vascular endothelial growth factor receptor 2 (VEGF-R2) hinsichtlich der Expression dieser Hypoxiemarker immunhistologisch untersucht. Für unterschiedliche Zellpopulationen (luminales Epithel …
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The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers
… RAC supplementation. Expression of GLUT4 and GLUT1 was not different after either biopsy. In experiment 2, there was no difference in final BW, HCW, BF, LMA, YG, DP, marbling score, chemical fat, or shear force. However, percent KPH tended to increase for CON. Variation between studies may be …
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