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Showing 1 to 18 of 18 for “"GLUT-1"”.
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic and hypoxic environments utilizing an <em>in-vitro</em> GBM model. The data accumulated in this …
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Evaluation of 18F FDG-PET/CT in Patients with Gastric Signet Ring Cell Carcinoma : Correlation with GLUT-1 Expression and Histologic Finding
… between FDG uptake and glucose transporter-1 (GLUT-1) expression in GSRC patients. MATERIALS AND METHODS: Forty patients (28 men, mean age 54±12) with histologically confirmed GSRC who underwent a pre-operative PET/CT were enrolled. The maximum standardized uptake value (SUVmax) was compared …
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Diagnóstico molecular en las anomalías vasculares congénitas y su repercusión terapéutica
… el papel de tres marcadores inmunohistoquímicos (GLUT-1, D2-40 y WT-1) en la identificación de anomalías vasculares de la infancia. Material y métodos. Se analizaron en total 103 pacientes pediátricos y 38 pacientes adultos con diagnóstico histológico de anomalía vascular basado en tinciones con …
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A Study Of The Molecular Genetics Of Renal Cell Carcinoma In Man
… factor 1-α (HJF-lα), glucose transporter one (GLUT-1), and vascular endothelial growth factor (VEGF) isoforms 165 and 189 mRNA in patients with renal cell carcinoma (RCC). Patients with RCC underwent radical nephrectomy at Derriford Hospital, Plymouth. Tumour as well as matched normal tissue …
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In-vivo and in-vitro study of mechanism of action of 4 hydroxyisoleucine as an amino acid derived from fenugreek seed with anti-diabetic and properties
… strongly dependent on new protein synthesis and GLUT 1 activity. GLUT 1 is widely available in most of the cells and it controls the basal glucose uptake independent of insulin. The connection between GLUT 1 and 4-hydroxyisoleucine effect in cellular level, supports the idea that …
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Glucose metabolism in the outer segments of photoreceptor cells : its involvement in the phototransduction process
… plasma membrane was also found to contain aGLUT-1 type glucose transporter of Mr 45K as detected by 3-O-methylglucoseuptake and exchange studies and Western blot analyses using type-specific glucose transporter antibodies. Solid-phase radio immune competitive inhibition studies indicated …
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… of P-gp, BCRP, MRP and Glucose 1 transporter (GLUT 1). While treatment with OHAs is becoming standard care in the management of GDM, little work has been done looking at those mechanisms in place to protect the fetus from such treatments. Future developments in the management of GDM are likely …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… of Hedgehog and Hippo signaling, including GLUT-1 BCL-2, BCL-xL and Bax. In summary, we determined that E. chaffeensis TRP120 interacts with Hedgehog and Hippo receptors and modulates Hedgehog and Hippo signaling via tandem repeat SLiMs to maintain an anti-apoptotic profile for ehrlichial …
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Explorative studies to understand if aldehyde dehydrogenase (ALDH) expression in colon cancer can be exploited as a target for therapeutic intervention. Expression profiling of ALDH7A1 in colorectal cancer
… however, results showed ALDH7A1, and GLUT-1 were co-expressed in CRC xenografts and tissue microarrays (TMAs) revealing hypoxia also impacts on ALDH7A1 expression in clinical samples. Both ALDH1B1 and ALDH7A1 were shown to be highly expressed in all patient samples, however, in-depth …
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Investigating the invasive and cytoprotective properties of the heme binding protein HRG-1 in cancer cells
… transporters such as the glucose transporter (GLUT-1) in cancer cells, and increases glucose uptake, which is required for cancer cell growth, metabolism and V-ATPase assembly. Heme is potentially cytotoxic, owing to its iron moiety, and therefore the trafficking of heme is tightly controlled …
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Molecular Approaches to the Genetics of Obesity: Mapping and Characterization of the Murine Diabetes (db) Gene
… of the markers which are linked to db - (Jun, Glut-1, Lmyc-1, and C8B,) map to human chromosome 1p31-p32, suggesting that db may be part of a syntenic group between human 1p and the distal portion of mouse chromosome 4. Additionally, distributions of age-controlled plasma [glucose] and …
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The impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep
… it must be sequentially transported by SLC2A1 (GLUT-1) on the maternal-fetal syncytial layer, then by SLC2A3 (GLUT-3) on the apical trophoblast membrane, and again by SLC2A1 on the basolateral trophoblast membrane. SLC2A1 is the most abundant placental facilitative glucose transporter, and as …
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Molecular Mechanisms of Metabolic Reprogramming in Pancreatic Cancer
… we observed the interaction of MUC13 with Glut-1 protein, which influences glucose uptake in cancer cells. This was confirmed through various assays such as: immunoprecipitation, immunofluorescence, co-capping and proximity ligation assay. The interpretation of inhibitor results envisaged …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… key glycolytic regulators, including GLUT-1, HK2, and PKM2, which are critical for glucose uptake and metabolism. This metabolic stress was accompanied by a substantial increase in reactive oxygen species (ROS) production, further contributing to cellular damage and apoptosis. The …
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EXPANSION OF CLINICAL PHENOTYPE AND USE OF KETOGENIC DIET IN RARE GENETIC CONDITIONS: GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME AND SCN8A-RELATED DISORDERS
… Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS) and conditions associated with pathogenic variants in the SCN8A gene. The aim was to expand the understanding of the clinical phenotype and disease progression, as well as to evaluate the efficacy of the ketogenic diet (KD) as a treatment. …
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Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival
… in the middle tertile of p53 expression and GLUT-1 positive and CD8 positive tumours. <br/><br/>Given the lack of studies identified in the systematic review in Chapter 2, the small number of patients included in Chapter 3, and the inconclusive results thus far, a larger cohort study …
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Small molecule inhibitors of lactate dehydrogenase A as an anticancer strategy
Embargo set by: Seth Robbins for item 73141 Lift date: 2017-01-21T19:56:18Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system