Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"GLT-1"”.
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
… of sodium-dependent glutamate transporters. GLT-1, the major glutamate transporter, is responsible for >90% of brain glutamate uptake. While previously thought to exist solely on astrocytes, the Rosenberg lab has identified GLT-1 as the major, if not only, glutamate transporter associated …
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Evaluation of the Role of Astrocyte Glutamate Transport and of Synaptic NMDA Receptor Subtype Representation in the Pathogenesis of PTSD
… the astrocytic glutamate reuptake transporter, GLT-1, and regional differences in expression of NMDA receptor subtypes in the development of a rat model of PTSD. We hypothesized that impaired astrocytic glutamate reuptake inhibits long-term memory processes, and that concurrent presence of …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… (GCPII) and the glutamate transporter subtype 1 (GLT-1), which contribute to the synthesis and extrasynaptic reuptake of glutamate, respectively. Ceftriaxone (CEF), a beta-lactam activator at the glutamate transporter subtype 1 (GLT-1), has shown preclinical promise in attenuating the rewarding …
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CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse
… NAc. Since the glutamate transporter subtype-1 (GLT-1) is a major regulator of extracellular GLU and upregulation of GLT-1 expression and function has been shown to attenuate reinstatement to cocaine-seeking, its expression was evaluated using immunoblot analysis of the NAc and PFC of rats that …
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
… reduces oxidative stress, and Ceftriaxone, a GLT-1 upregulator, would attenuate motor behavioral abnormalities and neurodegeneration in HD R6/2 mouse model.Although we did not observe any behavioral motor improvement with Colivelin and dPEG-Colivelin, we did, in fact, find significant …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… and 3) quantified changes in connexin 43, GLT-1, and GLAST to assess whether astrocytic glutamate transport may be altered in BIPN. The results observed in the first aim were that the rat BIPN model is characterized by selective mechanical hypersensitivity and a significant increase in wide …
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Glutamate and MDMA Neurobehavioral Toxicity
… mechanisms, including upregulation of the GLT-1 glutamate transporter with ceftriaxone, mGluR2/3 stimulation via LY379268, and inhibition of the cystine-glutamate antiporter (Xc-) with 4-S-carboxyphenylglycine (CPG) each attenuated the observed glutamate efflux. The results strongly suggest …
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A Role for glutamate and Gaba in attention-deficit/hyperactivity disorder: a study of the spontaneously hypertensive rat
… findings related to the glutamate transporter GLT-1, and the potassium-chloride co-transporter KCC2. The main findings of the present thesis were that glutamate-stimulated release of norepinephrine was elevated in SHR hippocampus compared to WKY and SD, and was via glutamate AMPA receptors. …