Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"GLP1R"”.
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
Glucagon Like Peptide-1 Receptor (GLP1R) is a key regulator of glucose metabolism, known to be expressed by pancreatic β-cells, gastric mucosa and hypothalamic appetite center. Recently, GLP1R mRNA has been detected on T lymphocytes; however, its function in these cells remains poorly understood. …
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Generation and use of new tools for the characterisation of gut hormone receptors
… insulin secretion by binding GLP-1 receptors (GLP1R) on pancreatic β-cells. Despite the therapeutic success, several extra-pancreatic clinical effects of GLP-1 remain unexplained. Here, a GLP1R monoclonal antagonistic antibody that can block GLP1R signalling in vivo has been developed and …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… at the Glucagon-Like Peptide-1 Receptor (GLP1R), a Class B1 GPCR with implications in glucose homeostasis. Its G protein-dependent signalling was measured, activating a wide range of G proteins, not confined to a certain subfamily. β-arrestin recruitment and internalisation were examined, …
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
… including novel loci in endothelin and GLP1R related genes.<br/>
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… models and the advent of weight loss-inducing GLP1R/GIPR dual incretin mimetics. 5-HT is a monoamine neurotransmitter and non-canonical gut hormone that has a wide impact on the gut and whole-body physiology. Most studies exploring EEC function have used either animal models or 2D cell lines. …
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Activation mechanisms of non-class A G protein-coupled receptors
… (GCGR), Glucagon-like Peptide 1 receptor (GLP1R), Parathyroid Hormone 1 receptor (PTH1R), Secretin Receptor (SCTR) and Pituitary Adenylate Cyclase 1 receptor (PAC1R), and fungal Class D receptor STE2, using large-scale all atom unbiased molecular dynamics simulations. To overcome the …
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Mapping the Feeding Circuitry in the Mouse and Human Brain
… mouse and human. We confirm co-expression of *GLP1R* with key transcripts of interest in the human hypothalamus using in situ hybridization. Collectively, this project has characterised the cellular architecture of the mouse and human hypothalamus (and mouse hindbrain) using transcriptomic …
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Investigation of the molecular mechanisms underlying the invasive phenotype in a panel of lung cancer cell lines
… a list of differentially expressed genes. GLP1R, KCNJ8 and TFPI2 genes were stably overexpressed and all induced invasion in non-invasive DLKP 17. Furthermore GLP1-R induced invasion could be reversed through siRNA induced silencing of the transgene. GLP1-R overexpression in non-invasive …
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UNVEILING THE ADVERSE EFFECTS OF POLYSTYRENE NANOPLASTICS IN THE HUMAN-DERIVED HEPG2-OA STEATOTIC-LIKE MODEL, VALIDATING DYSFUNCTIONAL HUMAN-DERIVED SW872 ADIPOCYTE IN VITRO MODELS FOR THE STUDY OF CARDIOMETABOLIC DISEASES, AND ASSESSING TRIMETHYLAMINE N-OXIDE IN A PLIC STUDY SUB-COHORT
… entrambi i modelli non esprimono il gene GLP1R e mostrano un’espressione speculare del gene SLC5A2. Sia SW872-OA e SW872-AUTO hanno mostrato una distinta attività mitocondriale; l'attività mitocondriale delle cellule SW872-AUTO diverge maggiormente rispetto alle cellule SW872, usate come …