Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"GLP1"”.
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Investigating the Structure and Physical Stability of Glp1-Like Peptides Using Mass Spectrometry
Working with fibrillation prone peptides is an adventure, to say the least, but harnessing their therapeutic potential is a challenge worth facing. On comparison to small molecules, peptides provide improved efficacy coupled with reduced toxicity; the difficulty lies in their pharmaceutical …
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Caratterizzazione della funzione e del comportamento dell'alfa cellula pancreatica: analisi dei meccanismi fisiopatologici implicati nell'insorgenza del diabete
… che le cellule alfa sono in grado di produrre GLP1 e che tale produzione di GLP1 è indotta dall'esposizione cronica al GLP1 stesso. Questo aspetto di notevole interesse per la patogenesi del diabete apre a nuovi spunti, la produzione a livello locale di GLP1 potrebbe servire all'isola per …
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Investigation of the molecular mechanisms underlying the invasive phenotype in a panel of lung cancer cell lines
… a list of differentially expressed genes. GLP1R, KCNJ8 and TFPI2 genes were stably overexpressed and all induced invasion in non-invasive DLKP 17. Furthermore GLP1-R induced invasion could be reversed through siRNA induced silencing of the transgene. GLP1-R overexpression in non-invasive …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
… not answer. Questions such as do islets produce GLP1 (glucagon-like peptide 1) receptor agonists and how is the islet peptidome altered in response to metabolic stress. I therefore carried out an investigation to address these questions. Targeted LC-MS methodology was used to search for …
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
… associated with endothelin function and with GLP1 receptors had significant effects on NAFLD.<br/><br/>This thesis applies an accurate and novel NAFLD definition to retrospective cohorts with EHRs, and found increased morbidity and mortality in individuals with this phenotype. A large …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
… (1.16-2.04), p = 0.003 for DPP-4i compared to GLP1-a (reference group)]. GLP-1a resulted also in a lower reporting rate of therapy failure in depressive patients compared to DPP-4i [ROR95=0.66 vs 0.86 in FAERS and ROR95=0.92 vs 1.06 in VigiBase, respectively]. Conclusions: GLP-1 analogues may …
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Glp-1 αγωνιστές και γαστρική κένωση: Μία συστηματική ανασκόπηση
… Παρά τα οφέλη τους σε πολλαπλά όργανα, τα GLP1 ανάλογα έχουν συσχετιστεί με καθυστέρηση της κένωσης του στομάχου, αυξάνοντας λοιπόν τον κίνδυνο εισρόφησης κατά την εισαγωγή στην αναισθησία. Από τα φάρμακα της κατηγορίας αυτής, διακρίνεται η σεμαγλουτίδη λόγω των ιδιαιτεροτήτων και της …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… at the Glucagon-Like Peptide-1 Receptor (GLP1R), a Class B1 GPCR with implications in glucose homeostasis. Its G protein-dependent signalling was measured, activating a wide range of G proteins, not confined to a certain subfamily. β-arrestin recruitment and internalisation were examined, …
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Investigating the Role of Inflammatory Biomarkers and Incretins in the Aetiology of Type 2 Diabetes and Coronary Heart Disease using Human Genetics
… could potentiate the protective effect of GLP1 agonists on diabetes without undue cardiovascular risk, while the effects of GIP on weight gain are counteracted by GLP-1.
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Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
… all of which have been shown to be altered by GLP1 agonists, although cardiac fibroblasts do not express the GLP-1R, highlighting indirect actions which appear to be largely mediated by macrophages. As such, macrophages were treated with high glucose which induced cytokine/chemokine expression, …
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The effects of a combined exercise programme aerobic and resistance on blood glucose, incretin, metabolic and inflammatory mediators that could control the diabetes and improve insulin sensitivity in type 2 diabetes patients
… different types of pharmacological therapy on GLP1. This study compared the effect of exercise on T2D plus medication in volunteers. It has been found that within T2D group only Metformin and SGT2-I group was improved. Both SGLT2 inhibitors and metformin have been found to affect body weight …
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Ús de l’ecografia per caracteritzar la distribució del teixit adipós abdominal i el seu impacte en el risc cardiovascular en diferents situacions clíniques i en resposta a diferents règims terapèutics
Introducció. L'obesitat és una malaltia altament prevalent i amb greus repercussions en la salut pública, no només per la seva associació amb múltiples comorbiditats metabòliques i cardiovasculars, sinó també per la seva relació amb diversos tipus de càncer. L'avaluació tradicional basada en …