Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"GLP-2"”.
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Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
… The gut derived hormones glucagon-like peptide (GLP)-1 and GLP-2 have been shown to signal through neuronal pathways and display postprandial hypolipidemic and hyperlipidemic actions respectively. Furthermore, activation of brown adipose tissue (BAT) through the sympathetic nervous system also …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… for TPN are necessary. Glucagon-like peptide-2 (GLP-2) may be a therapeutic agent as it reduces TPN associated atrophy and increases enzyme and transporter activity. To examine this, we coinfused GLP-2 with TPN and found increased ileal mRNA and protein abundance of the brush border …
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Influences of milk intake and dietary inclusion of a bioactive extract from the olive (Olea europaea) on glucagon-like peptide-2 and its effects on growth and intestinal health of dairy calves
… an intestinal peptide, glucagon-like peptide-2 (GLP-2), which stimulates proliferation, decreases apoptosis, enhances intestinal barrier function, and decreases intestinal inflammation. During diarrheic episodes and at weaning, feed intake is reduced, potentially decreasing gut release of trophic …
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Entwicklung von Secretin- und Glucagon-like peptide-2-Rezeptor-Antagonisten für die Tumordiagnostik
… GPCRs der Klasse B, das Glucagon-like peptide-2 (GLP-2), strukturell charakterisiert und für die zielgerichtete Tumordiagnostik optimiert. Um eine große Anzahl an Peptidvarianten untersuchen zu können, wurde die Methode der β-Arrestin2-GFP Translokation etabliert, die sich als äußerst vielseitig …
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Generation and use of new tools for the characterisation of gut hormone receptors
… of the gut hormones glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2). In recent years there has been a surge of interest in the enteroendocrine hormones particularly due to the success of GLP-1 mimetics in the treatment of …
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Pre-, pro-, and synbiotic modulation of the intestinal microbiota stimulates enteroendocrine mediated intestinal adaptation in piglets with short-bowel syndrome
… intestinal secretion of glucagon-like peptide-2 (GLP-2), an intestinotrophic hormone, stimulating innate intestinal adaptation. Treatments such as prebiotics and probiotics that increase luminal production of short-chain fatty acids (SCFA), especially butyrate, could further enhance this process …
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Nutrient Transport During Hypoperfusion
… hormones such as glucagon-like peptide-2 (GLP-2) to prevent the detrimental effects during NEC-injury. These results indicate that NEC-injury was created in the nutrient perfused loops by decreasing barrier function, increasing morphological injury, increasing inflammation and altering …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… hormones, namely glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, and obesity. Evidence suggests that fibers and short-chain fatty acids (SCFAs), particularly butyrate, …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… hormones, namely glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, and obesity. Evidence suggests that fibers and short-chain fatty acids (SCFAs), particularly butyrate, …
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In Vitro Characterization of Proglucagon Cleavage by PCI
… to produce glicentin, glucagon-like peptide-1 (GLP-1) and an extended form of GLP-2. PCI does not cleave Met-Gli, but does cleave Met-MPGF at a single site to produce Met- GLP-1 and an N-terminally extended version of GLP-2.|To simplify kinetic analysis of Met-PG processing by PCI, Met-MPGF …
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The role of the free fatty acid, lauric acid, in appetite regulation and its potential as an appetite-suppressant.
… region and stimulates glucagon-like peptide-1 (GLP-1) secretion, while both C12 and C10 stimulate cholecystokinin (CCK) secretion, however, the effect of C12 was much greater. A previous study in humans has also shown that intraduodenal administration of a long-chain fatty acid, such as oleic …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… mRNA abundance (the transcript coding for GLP-1 and GLP-2) was 2-fold higher in the cecum of butyrate-treated rats (P<0.0014). Butyrate also increased FFAR2 and FFAR3 mRNA abundance in the cecum. Taken together, butyrate increased glucose transport by the proximal intestine supported by an …
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Dietary supplementation of saccharin-based artificial sweeteners and capsicum oleoresin as a strategy to mitigate the negative consequences of heat stress on pig growth performance and intestinal physiology
… effects of heat stress (HS) by increasing GI GLP-2 production while capsicum oleoresin has been shown to reduce inflammatory response. Study objectives were to examine the effects of two artificial sweeteners, neohesperidin dihydrochalcone and saccharin, in combination with capsicum oleoresin …
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Calf intestinal health: assessment and dietary interventions for its improvement
… stevioside and a glutamate source could enhance GLP-2 secretion and thereby increase gut growth or health of newborn Holstein calves. No effect of any treatment on intestinal growth and development, as measured by epithelium histomorphological dimensions, cellular proliferation, gastrointestinal …