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Showing 1 to 20 of 164 for “"GLP"”.
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
… amyloid fibrillation of the therapeutic peptide GLP-1 and chemically modified forms of GLP-1. GLP-1, a metabolic hormone, has the ability to decrease blood sugar levels in a glucose-dependent manner by enhancing the secretion of insulin. Previous measurements of GLP-1 aggregation revealed that, …
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Αγωνιστές των υποδοχέων GLP-1: Ασφάλεια και οργανοπροστασία
Το πεπτίδιο τύπου γλυκαγόνης‑1 (GLP‑1) αποτελεί μια ινκρετίνη με κεντρικό ρόλο στη ρύθμιση του μεταβολισμού και της ενεργειακής ομοιόστασης. Δεσμεύεται σε εξειδικευμένους υποδοχείς GLP‑1 που εντοπίζονται σε διάφορους ιστούς του ανθρώπινου οργανισμού και είναι ευρέως γνωστό για τη συμβολή του στον …
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The Cardiovascular Effect of GLP-1 in Humans
The incretin glucagon-like peptide-1 (GLP-1) abolishes post-ischemic left ventricular contractility (stunning) in humans but the mechanism remains elusive. I hypothesized that this effect is mediated by peripheral or coronary vasodilatation. A comprehensive assessment of the haemodynamic effects of …
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Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
… The gut derived hormones glucagon-like peptide (GLP)-1 and GLP-2 have been shown to signal through neuronal pathways and display postprandial hypolipidemic and hyperlipidemic actions respectively. Furthermore, activation of brown adipose tissue (BAT) through the sympathetic nervous system also …
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Glp-1 αγωνιστές και γαστρική κένωση: Μία συστηματική ανασκόπηση
… Παρά τα οφέλη τους σε πολλαπλά όργανα, τα GLP1 ανάλογα έχουν συσχετιστεί με καθυστέρηση της κένωσης του στομάχου, αυξάνοντας λοιπόν τον κίνδυνο εισρόφησης κατά την εισαγωγή στην αναισθησία. Από τα φάρμακα της κατηγορίας αυτής, διακρίνεται η σεμαγλουτίδη λόγω των ιδιαιτεροτήτων και της …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… glucose homeostasis. Glucagon-like peptide 1 (GLP-1), which is an incretin hormone, activates the predominantly Gαs-coupled glucagon-like peptide 1 receptor (GLP-1R), which is a class B G protein-coupled receptor (GPCR), to mediate glucose homeostasis. It does so by promoting glucose stimulated …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
$\textbf{Background}$ Glucagon-like Peptide 1 (GLP-1) is a human incretin hormone that has been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… IV inhibitors, glucagon like peptide-1 (GLP-1) receptor agonists and selective sodium-glucose transporter-2 inhibitors (SGLT2i). These medications have transformed treatment pathways and prognosis for individuals with T2DM as well as obesity (GLP-1 receptor agonists), heart failure …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
… peptide therapeutic, glucagon-like peptide 1 (GLP-1). This peptide is responsible for many regulatory mechanisms affecting the level of glucose in the bloodstream. Unfortunately, it was shown that GLP-1 has a great propensity to aggregate over a wide pH range that inhibits its function. The …
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Central mechanisms underlying the synergistic anorectic effect of CCK and GLP-1 combination therapy
… (CCK) and Glucagon-like peptide-1 (GLP-1) are gut hormones produced in response to meal ingestion that promote satiety and meal termination. Co-infusion of long-acting CCK and GLP-1 receptor agonists have been shown to synergistically reduce food intake and body-weight in …
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SDOH, GLP-1 Prescription Patterns and MASLD-associated Liver Disease in a Real World Population
… examine predictors of advanced liver disease and GLP-1 RA receptor agonist use among a cross-sectional study of adults with metabolic dysfunction–associated steatotic liver disease (MASLD) and related conditions. Variables included diagnoses, prescriptions, demographics, BMI, diabetes, insurance, …
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Μελέτη των ιστολογικών βλαβών του κερατοειδούς από και τα συστατικά της slime - GLP και LPS
… aeruginosa (P.a.) and its components slime-GLP and LPS as well as the clinical aspects of the inducted lesions were studied. Experimental keratitis was induced (a) by a single intracorneal injection of live bacteria of the P.a. prototype strain PAC-IR (20-30 cell/per injection), (b) by a …
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ALAN DE SOUSA LIMA POLÍTICA DE PREÇOS PARA O GLP EM BOTIJÕES DE 13 KG (P13)
… da nova política da P etrobrás em relação ao GLP -P13 sobre as classes E e F. Para isso, a metodolo gia do trabalho será baseada em amostras estatísticas sobre o levantame nto dos preços médios do GLP-P13; volatilidade da demanda pelo produto ao longo do tempo e terá como apoio artigos …
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Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
… disease in diabetes. Glucagon-like peptide (GLP-1) is an incretin hormone, which confers proven glycaemic control in diabetes, and also demonstrates cardioprotective effects. Indeed, we have recently reported that the GLP-1 analogue, exendin-4, promotes specific benefits on cardiac …
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Studies on the operator-repressor-effector interactions in the glp regulon of Escherichia Coli K-12
All of the glp genes of Escherichia coli are subject to negative regulation by the glpR-encoded repressor (GlpR). Comparison of the repressor binding affinity for consensus and altered consensus operator regions showed that positions 3, 4, 5, 7 and 8 bp removed from the center of operator symmetry …
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Beyond cravings: A phenomenological exploration of relief among individuals with substance use disorders on GLP-1 medications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Association of GLP-1 Receptor Agonist Use with Kidney and Cardiovascular Outcomes in Stable Kidney Transplant Recipients
… of glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown promise in reducing cardiovascular events and improving kidney function in patients with type 2 diabetes. Due to these hopeful improvements, kidney transplant recipients (KTRs) have started using GLP-1RA. However, their effects …
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