Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"GLOBAL ISCHEMIA"”.
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Excitatory synaptic transmissions in striatal neurons after transient global ischemia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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TREM1-Mediated Neuroinflammation is Critical to Global Ischemia-Induced Neurodegeneration and Cognitive Deficits.
Global cerebral ischemia occurs when blood flow to the entire brain is significantly reduced; this occurs most commonly following cardiac arrest. Following global ischemia, there is delayed and selective loss of neurons in the hippocampal CA1, a critical brain region for learning and memory, …
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INVESTIGATION OF INOSINE AND HYPOXANTHINE AS BIOMARKERS OF CARDIAC ISCHEMIA IN PLASMA OF NON-TRAUMATIC CHEST PAIN PATIENTS AND A RAPID ANALYTICAL SYSTEM FOR ASSESSMENT
… of these patients are experiencing acute cardiac ischemia, but due to the shortcomings of current test methods, they are incorrectly diagnosed and discharged without appropriate treatment provided, thus leading to poor patient outcome and potential medical malpractice litigation.The goals of this …
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… Unfortunately, the myocardial damage due to ischemia in IHD may be worsened by reperfusion therapy, a phenomenon called ischemic-reperfusion (I/R) injury. Coronary vascular damage is a key feature of I/R injury. Among the coronary vascular structures, the endothelial glycocalyx is a delicate …
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Development of SiRNA Incorporated Surface Modified Polymeric Nanoparticle for the Potential Treatment of Global Cerebral Ischemia
Global cerebral ischemia is a cerebrovascular disease caused by cardiac arrest or cardiac surgery. Chronic and excessive neuroinflammation is a major contributor to cell death in the pathophysiology of global ischemia, likely having a detrimental effect on cognitive function. Bromodomain-containing …
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Higher Brain Neurons Succumb to Acute Stroke-Like Insult While Lower Brain Neurons Strongly Resist
… injury yet ‘lower’ brain regions better survive global ischemia, presumably because of better residual blood flow. Here we show that projection neurons in ‘lower’ brain regions of hypothalamus and brainstem intrinsically resist acute stroke-like injury independent of blood flow in the brain …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
… the heart against cellular damage caused by ischemia-reperfusion injury (I-R injury). Rapamycin is one such drug that has been shown to protect the heart against ischemia-induced cellular injury. Rapamycin(sirolimus) inhibits protein synthesis through inhibition of the mammalian target …
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The Effects of Estrogen Receptor -Alpha, Estrogen and Phytoestrogen on Global Myocardial Ischemia -Reperfusion Injury
… effects of estrogen receptor-alpha on myocardial ischemia-reperfusion injury were investigated in male estrogen receptor-alpha knockout (ERKO) and wild-type control mice (Control). The effects of estrogen and phytoestrogen were investigated in 6 control mice (Control). The effects of estrogen and …
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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury
… in most patients revived after cardiac arrest is ischemia and reperfusion (I/R) injury in the brain. Survival after brain I/R injury depends on the expression of new stress response proteins such as heat shock protein 70 (HSP70). Little is known about why recovering neurons are able to express new …
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EXERCISE-INDUCED ORGAN PROTECTION IN A MURINE MODEL OF CARDIAC ARREST AND RESUSCITATION
… rate of cellular death and tissue damage through global reperfusion injury. Despite decades of basic and clinical research, the prognosis after a resuscitated cardiac arrest continues to be poor. The substantial effects of cardiac arrest on neurologic function are a major contributor to the high …
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PHYSIOLOGICAL CONSEQUENCES OF CIRCADIAN DISRUPTION BY NIGHTTIME LIGHT EXPOSURE
… immunological, and behavioral functions. The global increase in the prevalence of obesity and metabolic disorders coincides with increases in exposure to LAN and shift work. Therefore, my first experiments examined whether exposure to LAN affects metabolism. Mice exposed to dimly lit (5 lux) …
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Interaction of exercise and simvastatin on myocardial ischemia-reperfusion (I/R) injury and post-ischemic cardiac function
… working hearts were subjected to 30 min of global ischemia followed by 30 min of normoxic reperfusion. Coronary effluents were used to determine lactate dehydrogenase (LDH) leakage and prostaglandin generation. Results: Cardiac function was similar in all groups prior to ischemia. Post I/R …
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Flavonoid protection of cardiac cells against ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury occurs following the majority of cardiac events including myocardial stenosis and heart surgeries. As reactive oxygen species are one of the major contributors to ischemia-reperfusion injury, strategies to prevent their effects may be directed towards …
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Assessment of Cardiac Function by Acoustic Radiation Force (ARF) Based Methods of Ultrasound Elastography
… changes in cardiac stiffness after induction of global ischemia. These changes were similar to the changes in the PV measure of diastolic stiffness. Furthermore, the results indicated that SWEI could be used to derive the relaxation time constant similar to the relaxation constant derived from …
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Transcriptional regulation of human mu-opioid receptor gene: functional characterization of activating and inhibitory transcription factors
… et al. 1998) and is up-regulated in response to global ischemia (Calderone et al. 2003) and induction of epilepsy (Spencer et al. 2006). Thus, the REST concentration seems to influence its function and the expression of neuronal genes, and may have different effects in embryonic and …