Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"GLIC"”.
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
… my thesis, I used the two prokaryotic homologs, GLIC and ELIC, to explore how amino acid interactions at the interface between M4 and M1/M3 influence channel activity. Alanine scanning mutagenesis of this interface shows that disruption of almost any interaction in GLIC leads to a loss of folding …
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Using molecular dynamics to probe protein conformational transition mechanisms at the membrane surface
Far from being a passive demarcation between the cell and the environment, the cellular membrane is a vibrant and dynamic ecosystem. Membrane proteins constitute an integral piece of this ecosystem, allowing for communication between the cell and its environment that is necessary for adaptation and …