Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"GK rat"”.
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Regulation of Insulin Secretion in Relation to Nitric Oxide, Carbon Monoxide and Acid alpha-Glucoside Hydrolase Activities
… insulin release in parallel. In the diabetic GK rat we found several abnormalities that could, at least in part, explain the impaired response to glucose seen in this diabetic animal model. We show that the GK rat has a dysfunctional lysosomal/vacuolar system in the islets of Langerhans, and …
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The impact of glucotoxicity on pancreatic β-cell function
… hyperlipidemic ZDF (fa/fa) and hyperglycemic GK rat, we found that chronic hyperglycemia in the absence of hyperlipidemia almost abolish GPR40 expression in the islet cells and abrogate the FFA-induced secretory effects. We suggest that this might be an important contributing factor for …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… 2 DM (T2DM). Epidemiological studies have demonstrated a role of hyperglycaemia (HG) in eliciting adverse cardiac and renal outcomes including heart failure (HF), diastolic and renal dysfunction. This study investigated the effect of HG on left ventricle (LV) and kidney structural remodelling, …
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Mitochondrial and chromosomal genomics in type 2 diabetes
… we setup a reciprocal cross between the diabetic GK and the normoglycaemic F344 rats. This reciprocal cross consisted of two individual crosses that shared identical nuclear DNA haplotypes while they differed in the mtDNA haplotypes at 110 nucleotide positions. We performed cross-separated linkage …