Global ETD Search
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Showing 1 to 2 of 2 for “"GIRK channels"”.
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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel
… receptors (GPCRs), which in turn activate ion channels that modify the electrical properties of cardiac pacemaker cells. Sympathetic stimulation accelerates heart rate through activation of beta-adrenergic receptors (βARs), which open excitatory ion channels through the stimulatory G protein …
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GPCR to Channel Communication in a Membrane Signaling Pathway
… cyclic nucleotide–gated (HCN) channels, resulting in an accelerated heart rate. In contrast, activation of M2 muscarinic receptors (M2Rs) and the inhibitory G protein (Gαi) opens G protein-gated inward rectifier K⁺ (GIRK) channels, slowing the heart rate. In addition to the Gαs …