Global ETD Search

Activity-dependent regulation of GIRK and Kv7 channels in homeostatic plasticity and epilepsy

Baculis, BrianUniversity of Illinois at Urbana-Champaign2022

Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms

uiuc Repository record for Activity-dependent regulation of GIRK and Kv7 channels in homeostatic plasticity and epilepsy (opens in a new tab)

GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel

Touhara, Kouki

… G protein-gated inwardrectifier potassium (GIRK) channels. Interestingly, βARs also release the very same free Gβγ, but GIRK is not activated. The molecular mechanism underlying this specificity is poorly characterized. What is the molecular basis behind signaling specificity? It has been …

rockefeller Repository record for GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel (opens in a new tab)

GPCR to Channel Communication in a Membrane Signaling Pathway

Zhang, Yuxi2025

… (Gαi) opens G protein-gated inward rectifier K⁺ (GIRK) channels, slowing the heart rate. In addition to the Gαs and Gαi pathways, there is also the Gαq signaling pathway. In this pathway, activation of Gq-coupled GPCRs can lead to the activation of phospholipase Cβ (PLCβ). This enzyme can then …

rockefeller Repository record for GPCR to Channel Communication in a Membrane Signaling Pathway (opens in a new tab)

Efecto del beta Amiloide (25-35) sobre la respuesta inhibitoria mediada por canales Girk en la sinapsis fimbria-CA3 del hipocampo

Nava Mesa, Mauricio Orlando2011

salamanca Repository record for Efecto del beta Amiloide (25-35) sobre la respuesta inhibitoria mediada por canales Girk en la sinapsis fimbria-CA3 del hipocampo (opens in a new tab)

Regulation der Neurotransmission im zentralen Nervensystem durch alpha2-adrenerge Rezeptoren

Bücheler, MarkusUniversität Würzburg

… Diese Zellinien wurden transient mit GIRK-Kanälen transfiziert, um die durch Stimulation mit Noradrenalin resultierenden Kaliumströme mit der "patch-clamp"-Technik zu messen. Dabei ergab sich kein signifikanter Unterschied zwischen alpha2A- und alpha2C-AR bezüglich der …

wurz-thes Repository record for Regulation der Neurotransmission im zentralen Nervensystem durch alpha2-adrenerge Rezeptoren (opens in a new tab)

A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory.

Johansson, FredrikAssociative Learning2015

… the G-protein activated K+ channel family Kir3/GIRK (paper III). The implication is that a learned and adjustable timing of a metabotropic signaling cascade constitutes a physical memory of temporal duration. A theoretical model (paper IV) describes how this could be accomplished by a learning …

lund Repository record for A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory. (opens in a new tab)

Characterization of Rimonabant effects on G protein activity

PORCU, ALESSANDRAUniversità degli Studi di Cagliari2016

… to demonstrate that SR induced the inhibition of GIRK channel activity by acting directly on G protein, we use a GPCR-free experimental setup (i.e. whole cell patch clamp experiments were performed in CHO cells transfected with GIRK1/2). The main finding of this study is that SR, at micromolar …

cagliari Repository record for Characterization of Rimonabant effects on G protein activity (opens in a new tab)