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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 11 of 11 for “"GIPR"”.

  1. Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)

    Herbach, NadjaLudwig-Maximilians-Universität

    … insulinotropic polypeptide receptor (GIPR dn) Gastrointestinal hormones like glucose-dependent insulinotropic polypeptide have recently been shown to be involved in the pathogenesis of diabetes mellitus in humans and animals models of diabetes mellitus. The aim of this study was to …

    lmu-germany Repository record

  2. Generation and use of new tools for the characterisation of gut hormone receptors

    Biggs, Emma KateUniversity of Cambridge2019

    … a fluorescent reporter under the control of the Gipr promoter has been used here to identify GIPR expressing cells. This model showed GIPR expression in the pancreas, adipose tissue, duodenum and nodose ganglia. Surprisingly GIPR expressing cells were found centrally, in areas of the hypothalamus …

    cambridge Repository record

  3. The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity

    Hansford, RobertUniversity of Cambridge2023

    … insulinotropic polypeptide receptor (GIPR) is enriched in mature oligodendrocytes of the ME, pre-empting speculation that the oligodendrocyte lineage cells of the ME may be responsive to endogenous GIPR signalling. This thesis demonstrates that the genetic ablation of *Gipr* in …

    cambridge Repository record

  4. Drug discovery at class A and class B GPCRs

    Hilšer, AnnaUniversity of Cambridge2022

    … and gastric inhibitory polypeptide receptor (GIPR), a class B GPCR. Given the possible therapeutic effects of modulating GIPR signalling pathway in diabetes and obesity, the primary objective of this thesis was to discover and improve GIPR allosteric modulators using both in silico and in …

    cambridge Repository record

  5. Investigating the Role of Inflammatory Biomarkers and Incretins in the Aetiology of Type 2 Diabetes and Coronary Heart Disease using Human Genetics

    Bowker, NicholasUniversity of Cambridge2020

    … associations of a known missense variant in GIPR, E354, and infer specificity and potential beneficial or harmful effects of GIPR mono agonism. Bayesian multi-trait colocalisation was used to distinguish trait clusters driven by shared causal variants to identify independent causal variants …

    cambridge Repository record

  6. LNX1 and LNX2 in the central nervous system: linking behavioural, cellular and molecular perspectives

    Cioccarelli, LauraUniversity College Cork2025

    … with growth-related proteins, such as GHRHR, GIPR, TRIP6 and IGF1R were also characterised. In parallel, a possible role of LNX2 in stress response was examined in Chapter 4. In cultured cortical neurons, LNX2, but not LNX1p70, was transcriptionally induced following neuronal activation, …

    cork Repository record

  7. Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus

    Mansur, Sity AishahUniversity of South Australia2015

    … studies on the impact of genetic deficiencies of GIPRs and GLP-1Rs on bone mineral density and content. Further studies characterised the beneficial effects of incretin-based therapies on metabolic control, bone microstructure and bone mechanical integrity in animal models of pharmacologically-, …

    uthm Repository record

  8. The interplay between genes and dietary factors in the aetiology of Type 2 Diabetes Mellitus

    Li, Sherly (Xueyi)University of Cambridge2018

    … acids) and genetic variants in or near TCF7L2, GIPR, CAV2 and PEPD (p<0.05) on T2D. All studies were observational with moderate to serious risk of bias and limitations that included lack of adequate adjustment for confounders, lack of reported replication and insufficient correction for …

    cambridge Repository record

  9. Receptor activity-modifying protein and small molecule modulation of the gastric inhibitory polypeptide receptor

    Harris, MatthewUniversity of Cambridge2020

    cambridge

  10. Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids

    Guccio, NunzioUniversity of Cambridge2024

    … and the advent of weight loss-inducing GLP1R/GIPR dual incretin mimetics. 5-HT is a monoamine neurotransmitter and non-canonical gut hormone that has a wide impact on the gut and whole-body physiology. Most studies exploring EEC function have used either animal models or 2D cell lines. …

    cambridge Repository record

  11. Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells

    Woollams, CarolineResearchSpace@Auckland2013

    … of pancreatic progenitor cells which expressed GIPR, PDX-1, and GPR40, but there was no evidence of further maturation into insulin-producing endocrine cells. ASCs were subjected to stage-specific differentiation protocols designed to mimic the natural differentiation stages of pancreatic cell …

    auckland-ms Repository record