Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"GHR"”.
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Verifying the Deletion of Growth Hormone Receptor Using a Quantitative Polymerase Chain Reaction at the mRNA Level in Tissue-Specific GHR-/- Mice
… diabetes in both mice and humans. GH receptor (GHR) gene disrupted mice (GHR-/- mice) have been genetically modified to lack the GHR and GH action. GHR-/- mice are extremely insulin sensitive and have an extended life span. The contribution of individual tissues to the phenotype of GHR-/- mice …
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A functional analysis of growth hormone receptor promoter regions in swine
… Growth hormone (GH) and its receptor (GHR) play critical roles in regulating growth, development, and reproductive function in animals. GHR expression in the liver is critical for postnatal growth and is regulated by tissue-specific promoters. While promoter 1 (P1) is considered the …
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Chained Aggregation and Control System Design: A Geometric Approach
… of the Generalized Hessenberg Representation (GHR) of a linear time-invariant control system. It is shown that the GHR explicitly exhibits a sequence of observability subspaces, { (,i)}. By studying these subspaces in this specific basis, a number of results follow.
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Effects of Growth Hormone on Circulating Resistin Levels in Mice
… (GHA) mice and growth hormone receptor knockout (GHR-/-) mice are dwarf and obese with either normal or higher insulin sensitivity, respectively. Blood plasma samples from three male mice lines: bGH, GHA, GHR-/- along with their littermate wild type (WT) control groups were collected following an …
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Effects of Growth Hormone and Insulin-Like Growth Factor-I on Milk Protein Gene Expression and Nutrient Uptake and Cell Proliferation in Clonal Bovine Mammary Epithelial Cells
… protein genes in MAC-T cells transfected with GHR expression plasmid. Cotransfection analyses indicated that GH also stimulated (P < 0.01) luciferase reporter gene expression from the promoters of the four milk protein genes in MAC-T cells. These findings together with the fact that GHR mRNA …
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Near aggregation: a time and frequency domain analysis using state trajectories and transfer function residues
… The Generalized Hessenberg Representation (GHR) and Dual GHR are examined throughout this analysis. It is finally shown that for SISO systems, the residue norm may be expressed in terms of certain parameters of the Dual GHR.
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Application of Naturalistic Truck Driving Data to Analyze and Improve Car Following Models
… the naturalistic data. The models used are the GHR, Gipps, Intelligent Driver, Velocity Difference, Wiedemann, and the Fritzsche model. This research effort also analyzes the Wiedemann car-following model using car-following periods that occur at different speeds. The Wiedemann car-following …
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Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism
… and may be connected to the peripheral signals ghrelin and leptin. The overall aim of this thesis was to investigate how these different hormonal systems interact. To investigate the metabolic role of GH in the CNS, transgenic mice that overexpress bovine GH in the CNS (GFAP-bGH) were studied. …
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A geometric analysis of model reduction of linear systems
… Balanced, Jordan canonical form, and dual GHR representations are shown to be state space realizations which naturally identify the reducing subspaces based on these measures. Several results unifying these methods are given. In another approach, we show that the reducing subspaces can be …
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Growth hormone and somatolactin function during sexual maturation of female Atlantic salmon
… it is similar to previously cloned GH receptors (GHRs) of non-salmonids. The ligand-specificity of the GHR/SLR is unclear. Little is known about the role of the SLs in sexual maturation of fish. The aim of this thesis has been to increase our knowledge about the regulatory role(s) of both the …
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Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency
… response to growth hormone replacement therapy (GHRT) in GH deficient (GHD) adults. The patients were part of a cohort of adults with hypopituitarism and severe GHD who were studied before and after 12 months of GHRT. The dose regimen was individualized in order to attain normal IGF-I levels. …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… HP, GSTM1), growth hormone/IGF-1 axis genes (GHR, IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, serum NEFA concentrations were higher at -2 and -1 week relative to calving and serum BHBA concentrations were also higher at -2 wk. We also observed a …
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Analysis of the Relationship Between Growth Hormone Receptor Polymorphism rs6180 and Craniofacial Morphological Changes Associated with Herbst Appliance Therapy
… (SNP), rs6180, of the Growth Hormone Receptor (GHR) gene with various craniofacial length parameters in patients who have received Herbst appliance therapy as part of orthodontic treatment. An initial lateral cephalometric radiograph was taken along with two buccal cheek swabs. The cells …
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Nutritional Regulation of Serum Insulin-Like Growth Factor-I Concentration in Cattle
… with decreased expression of GH receptor (GHR) mRNA and protein in the liver. Food deprivation was also associated with increased mRNA expression of two inhibitors of the GHR signaling pathway, suppressor of cytokine signaling-2 (SOCS2) and cytokine-inducible SH2 protein (CIS). These …
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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
… substrate peptides of growth hormone receptor (GHR) and erythropoietin receptor (EpoR) were solved by X-ray crystallography with a goal to elucidate the SOCS2 recognition mechanism. Different interactions of the peptides were observed in the structures as a consequence of divergences in the …
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Μοριακοί μηχανισμοί ελέγχου της μετάδοσης του σήματος της αυξητικής ορμόνης σε παιδιά με σοβαρή ανεπάρκεια στην αύξηση
… STATs για θέση πρόσδεσης με τον υποδοχέα GHR ή συμμετέχουν στην αποδόμηση του JAK2/GHR μέσω ουβυκουιτίνης/προτεασώματος. Η αδυναμία φωσφορυλίωσης του STAT3 και JAK2 φαινεται να προσπερνάται με χρήση εναλακτικής οδου. Με ‘διασυνομιλία’ της GH με το μονοπάτι του EGF. Συγκεκριμένα η GH …
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Naturalistic Driving Data for the Analysis of Car-Following Models
… greater, and the Gaxis-Herman-Rothery model (GHR) and the Intelligent Driver Model (IDM) errors 143 percent and 86 percent greater, respectively. Additionally, the RPA model provides the flexibility for a driver to change vehicles without the need to recalibrate parameter values for that …
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Otimização multiobjetivo da geometria de edificações residenciais energeticamente eficientes por meio de algoritmos genéticos
… os indicadores graus-hora de resfriamento (GHr) e de aquecimento (GHa) com temperaturas base de 26°C e 18°C, respectivamente. Identificou-se como parâmetros de maior impacto sobre o desempenho: área útil, inclinação da cobertura, áreas envidraçadas e áreas de vão de ventilação. Graus-hora …
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Ovarian and Growth Hormone Regulation of Mammary Growth and Transcript Abundance in Prepubertal Dairy Heifers
… However, bST reduced the relative abundance of GHR, signal transducers and activators of transcription-5b and suppressors of cytokine signaling-2 in mammary PAR. Transcript abundance of IGF-axis molecules, estrogen responsive genes and proliferation markers in MFP was not affected by ovariectomy …
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Genetics of Obesity and Diabetes in the IRAS Family Study
… of interest, and the other traits measured was GHR. SI was associated with SNPs rs6870962 (p-value=0.009) [Genotypic means: 1/1 (1.57(400)), 1/2 (1.86(81)), 2/2 (1.94(10))], and rs6883523 (p-value=0.009) [Genotypic means: 1/1 (1.68(371)), 1/2 (1.49(114)), 2/2 (0.82(9))]. In summary, regions that …
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