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Showing 1 to 20 of 136 for “"GFAP"”.

  1. Nachweis von saurem glialen Faserprotein (GFAP) in humanem Serum und erste klinische Ergebnisse

    Magerkurth, OlafLudwig-Maximilians-Universität

    … in der Kardiologie, erscheint hoch. GFAP wurde 1971 von Eng erstmalig aus Multiple Sklerose Plaques isoliert. GFAP ist ein 50 ± 1 kDa großes Protein, welches in einer wasserlöslichen und wasserunlöslichen Form existiert. GFAP gehört zu der Gruppe der Intermediärfilament-Proteine, die …

    lmu-germany Repository record

  2. Überlebenszeitabhängige Änderungen der zerebralen IL-6- und GFAP-Expression nach letalen Schädel-Hirn-Traumen

    Trautz, FlorianUniversität Leipzig

    … Intermediärfilamentes Saures Gliafaserprotein (GFAP) hinsichtlich ihrer Aussagekraft zur Detektion eines Schädel-Hirn-Traumas (SHT) und der Abschätzung des Überlebenszeitintervalls zwischen Erleiden der Gewalteinwirkung und dem Todeseintritt. Hierzu wurden Hirngewebsproben von 75 Verstorbenen im …

    qucosa-diss

  3. Papel das reservas intracelulares de cálcio no efeito de aminoácidos excitatórios sobre a fosforilação da proteína ácida fibrilar glial (GFAP) em hipocampo de ratos jovens

    Oppelt, Daniela Mendes2002

    A proteína ácida fibrilar glial (GFAP) é uma proteína da classe dos filamentos intermediários, exclusivamente expressa em astrócitos no sistema nervoso central (SNC). A função específica da fosforilação desta proteína é ainda desconhecida. No entanto, tem sido demonstrado que o equilíbrio dinâmico …

    brazil-ufrgs Repository record

  4. The role of light signaling on astrocytic morphological plasticity in the adult male rat suprachiasmatic nucleus

    Irving, Samuel JacobUniversity of Illinois at Urbana-Champaign2017

    … marker, glial fibrillary acidic protein (GFAP), is expressed in much higher levels compared to other local hypothalamic regions containing neuronal fibers. GFAP allows for the rough estimation of the overall astrocyte cell shape and despite a lack of in vivo polymerization dynamics, in …

    uiuc Repository record

  5. Systematische Charakterisierung und Untersuchung der Inzidenz von Myelitis-assoziierten Autoantikörpern bei akuten Myelitiden

    Emad, JenniferChristian-Albrechts-Universität zu Kiel

    … (AQP-4) und glial fibrillary acidic protein (GFAP) Antikörpern bei PatientInnen mit Myelitis im Vergleich zu einer Kontrollkohorte. Es erfolgte eine retrospektive Rekrutierung von PatientInnen mit Myelitis und einer Kontrollkohorte. Kohortengröße jeweils 110 PatientInnen. Demografische, …

    cau-kiel Repository record

  6. Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10

    Boztug, Kaan

    … <br>These glial fibrillary acidic protein (GFAP)-CXCL10 transgenic mice developed spontaneous, transgene dose- and age-related leukocyte infiltrates in perivascular, meningeal and ventricular areas of the brain that were composed of, surprisingly, predominantly neutrophils, and lower numbers …

    freiburg-diss Repository record

  7. Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment

    Holden, Lindsay J.Aston University2007

    … specific glial fibrillary acidic protein (GFAP) is a hallmark of reactive gliosis and is widely used as a marker to identify the response. In order to develop a reliable, sensitive and high throughput astrocyte toxicity assay that is more relevant to the human response than existing animal …

    aston Repository record

  8. Enteric and hepatic glia-like cell reactivation after astrocyte-directed twinkle helicase loss

    Sarkola, EmmiHelsingin yliopisto2024

    … is created by using a glial fibrillary acid (GFAP) promoter, driving a Cre recombinase that together with LoxP sequences leads to a knockout of the twinkle gene in the cells expressing GFAP. In this thesis I studied whether the astrocytic twinkle gene knockout (TwKOastro) affects non-nervous …

    helsinki Repository record

  9. The effect of weight loss on circulating biomarkers of brain health and executive function

    Herra, Lindsay MarieVirginia Tech2020

    … B (S100B), and glial fibrillary acidic protein (GFAP). Serum samples (n=21; 50-75 years, BMI 25-40 kg/m2) were pooled from two prior weight loss studies. Fasting blood measurements were taken before and after 8- or 12-weeks of hypocaloric diet-induced weight loss (1200 or 1500 kcal/d). Body Mass …

    vt Repository record

  10. Pharmacological inhibition of CK2: the effect of an FDA designated orphan drug on pathology, neuroinflammation, and glial phenotypes in Huntington’s disease

    Pelzel, Ross2026

    … Additionally, we explored the unknown role of GFAP+ astrocytes in the striatum, which cluster around white matter fascicles originating from the secondary motor cortex (M2). The M2-striatum pathway is involved in motivation and degeneration in HD can lead to apathy, one of the major psychiatric …

    umn Repository record

  11. Die Rolle von CNTF und LIF bei glialen Reaktionen nach Läsion des Nervus opticus

    Trautmann, Nikolaus

    … Während unoperierte CNTF-/--Tiere eine geringere GFAP-Expression der Müllerzellen zeigen, kommt es nach Läsion genau wie im Wildtyp zu einer Aktivierung der Müllerzellen. Weiterhin wird in CNTF-/-- und Wildtyp-Tieren der STAT3-Signalweg aktiviert. Auch Mikrogliazellen werden in CNTF-/-- und …

    freiburg-diss Repository record

  12. The Role of Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis

    Macauley-Rambach, Shannon2009

    … upregulation of glial fibrillary acidic protein: GFAP), a marker of astrocyte activation, in the thalamus, cortex, and cerebellum. Focal regions of GFAP upregulation were an accurate predictor of future sites of neuronal loss. Since astrocyte activation is both helpful and harmful to an injured …

    wustl Repository record

  13. Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea

    Rova, Cherokee Rose Lee

    … cells while the glial fibrillary acidic protein (GFAP) promoter drove expression in the non-sensory support cells. This in vivo study was designed to determine if these results might be recapitulated in the guinea pig model and was conducted in three separate phases. In Study 1, guinea pigs were …

    montana-tech Repository record

  14. Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea

    Rova, Cherokee Rose Lee

    … cells while the glial fibrillary acidic protein (GFAP) promoter drove expression in the non-sensory support cells. This in vivo study was designed to determine if these results might be recapitulated in the guinea pig model and was conducted in three separate phases. In Study 1, guinea pigs were …

    montana Repository record

  15. Exploring the potential for biomarkers to aid forensic diagnosis of traumatic brain injury (TBI) – a systematic literature review and meta-analysis

    Velcich, CarlyDepartment of Pathology2024

    … B (S100β) and Glial Fibrillary Acidic Protein (GFAP), have been assessed as potential TBI biomarkers. The aim of this review was to evaluate recent articles that investigated these biomarkers in relation to TBI and relate this to a forensic diagnostic context. Methods: This review included 44 …

    cape-town Repository record

  16. Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke

    Aimable, MargauxThe University of Edinburgh2020

    … protective effects. Nrf2 overexpression in GFAP-expressing astrocytes in a mouse model (GFAP-Nrf2 mice) has been shown to confer protection against inflammation and oxidative stress in neurodegenerative models. Following ischaemia, GFAP-Nrf2 mice presented a significant reduction of neuronal …

    edinburgh Repository record

  17. The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia

    Nadeau, JoelleUniversity of Saskatchewan2013

    … channel Kir4.1, glial fibrillary acidic protein (GFAP), SGC p75NTR, connexin 43, we intrathecally infused p75NTR anti-sense oligonucleotides (AS OGN), previously shown by Obata et al. (2006) to effectively suppress p75NTR expression in intact neurons. Male, Wistar rats were divided into three …

    sask Repository record

  18. Morphological and Immunocytochemical Investigation of Canine Oligodendrogliomas

    Higgins, Michael AnthonyVirginia Tech2006

    … and three immunocytochemical markers (GFAP, EGFR, and Ki-67 labeling index) and the degree of malignancy, as defined by WHO grading criteria, of 15 canine oligodendroglial tumors. Of the histomorphologic variables examined, mitoses and cellular atypia were significantly greater in Grade …

    vt Repository record

  19. Identification and characterization of glial and neuronal cells in vitro and in bone marrow

    Frentzou, Georgia AlkistisUniversity of Central Lancashire2002

    … Consequently, the cultures were subjected in GFAP, Gal C, NSE and PR antibodies. The results have shown that oestrogen had no significant effect on the development of the cells. Staining of glial cells with Haematoxylin and Eosin and taking measurements for cell diameter, nucleus diameter and …

    cent-lancashire Repository record

  20. Studying the glial cell response to biomaterials and surface topography for improving the neural electrode interface

    Ereifej, Evon S.2012

    … have an upregulation of intermediate filaments GFAP and vimentin expression, and filament formation (Buffo et al., 2010; Gervasi et al., 2008). </p> <p>Current approaches towards inhibiting the initiation of glial scarring range from altering the geometry, roughness, size, shape and materials of …

    wayne-thes Repository record

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