Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"GEMM"”.
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Performance Analysis of the Apple AMX Matrix Accelerator
… study on AMX specific matrix multiplication (GEMM) design, and (iii) an interpretable rule-based latency model that predicts cycle counts for short AMX instruction sequences. First, microbenchmarks quantify AMX load/store and compute limits across matrix and vector modes and data types. We …
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… a novel genetically engineered mouse model (GEMM) and derived primary cell lines from them to explore the role of microRNA-200 in early EMT and immune changes. Our model combines conditional activation of Kras<sup>G12D</sup>, Trp53<sup>R172H</sup>, and deletion of miR-200<sup>141/c</sup> …
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Integrated multiparametric deep spatial phenotyping of mouse models of lung adenocarcinoma
… taken from a genetically engineered mouse model (GEMM) of lung adenocarcinoma. I extracted biomarker expression levels and morphological, textural, and spatial motifs of single cells from the imaging data and used these features to train algorithms to predict tumor histologic grade, a measure …
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… a novel genetically engineered mouse model (GEMM) for PanNETs focused on the top inactivating mutations observed in human disease. Lastly, we have identified therapeutic vulnerabilities of NSD3 that target growth-signaling pathways and bromodomain inhibition rendering tumor growth in …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… Using a genetically engineered mouse model (GEMM) of metastatic TNBC (MMTV-Prune1/Wnt1), Prune1 was found to enhance glycolysis and OXPHOS, promoting lung metastases by inhibiting GSK-3 activity. Prune1's mitochondrial localization and interaction with ATP5A1 highlight its role in …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… the generation and characterization of a GEMM which gives rise to metastatic sRCC: deletion of Hippo pathway kinases Lats1/2 in adult kidney epithelia. Lats1/2 mutant tumors respond to immune checkpoint inhibition (ICI), as is seen in some human sRCCs. Bioinformatic analysis reveals an …
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Constructing and deconstructing cancer using CRISPR-Cas9
… existing genetically engineered mouse models (GEMMs) have led to critical insights into the initiation and progression of human cancer, their use for rapid functional characterization of new cancer genes has been historically limited, partly due to the cost and time required to generate …
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… Sparc-null (Sparc-/-) mice were crossed with a GEMM of PDA, KIC (LSL KrasG12D/+; Ink4aArflox/lox; p48Cre/+). Survival was reduced and tumors were more aggressive in Sparc-/-; KIC mice. Tumors from these animals also displayed elevated Ddr1-mediated signaling. Human PDA, and primary PDA cell …
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Developing Novel Models and Therapeutics for ZFTA-RELA Ependymoma
… Although genetically modified mouse models (GEMM) of cancers are useful for understanding the biology and treatment of cancer, no GEMMs of ependymoma have been generated: current models require invasive intracranial injection of cells or gene constructs during embryogenesis. This thesis …
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A broadened HLA ligandome uncovers new immunotherapy targets for pancreatic cancer + A prime editor mouse to model a broad spectrum of somatic mutations
… of a genetically engineered mouse model (GEMM) for performing prime editing in vivo. This system represents a rapid alternative to traditional cancer mouse models, which often take months or years to develop. Through a Creinducible prime editor enzyme encoded in the mouse germline, prime …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… FUS-CHOP genetically engineered mouse model (GEMM). ChIP-seq/CUT&RUN mapped genome-wide binding sites of FUS-CHOP and identified DNA-binding motifs for the fusion oncoprotein. Co-IP of irradiated human MLPS cell lines were performed to evaluate post-translational modification of FUS-CHOP after …
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Low-power System-on-Chip Processors for Energy Efficient High Performance Computing: The Texas Instruments Keystone II
… implementation of matrix multiplication (GEMM) for the BrownDwarf system. The BrownDwarf utilizes both Keystone II and Keystone I SoCs through a point-to-point interconnect called Hyperlink. Details of how a novel message passing communication framework across Hyperlink was implemented to …
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Low-power System-on-Chip Processors for Energy Efficient High Performance Computing: The Texas Instruments Keystone II
… implementation of matrix multiplication (GEMM) for the BrownDwarf system. The BrownDwarf utilizes both Keystone II and Keystone I SoCs through a point-to-point interconnect called Hyperlink. Details of how a novel message passing communication framework across Hyperlink was implemented to …
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Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
… we employed genetically engineered mouse models (GEMMs) of PDAC with deletion of the EMT transcription factor (TF) <em>Zeb1</em> (Zeb1<sup>cKO</sup>) and orthotopic models with conditional deletion of the EMT TFs <em>Snail</em> and <em>Twist</em> (ST<sup>cKO</sup>) to evaluate the role of EMT …