Global ETD Search
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Showing 1 to 20 of 74 for “"GEMCITABINE"”.
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Synthesis of gemcitabine and it's tetrafluorinated analogues
… 2-deoxy-2,2-difluorocytidine nucleoside analogue gemcitabine has been achieved. Starting from the known 3,5-O-dibenzoyl-2- deoxy-2,2-difluororibose, the nucleobase moiety is constructed in a linear fashion, using amino- or urea glycosylation methodology. This methodology has also been employed to …
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Molecular mechanisms of acquired gemcitabine resistance in pancreatic cancer
Most pancreatic cancer patients receiving gemcitabine chemotherapy eventually develop resistance to gemcitabine. To improve survival and prognosis of pancreatic cancer patients, better understanding the mechanisms of gemcitabine resistance and discovery of new therapeutic targets are required. In …
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Development and Characterization of Polymeric Nanoparticulate Delivery System for Hydrophillic Drug: Gemcitabine.
Gemcitabine is a nucleoside analogue, used in various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with gemcitabine include its short half-life and highly hydrophilic nature. The objectives of this …
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Chemosensitization of Hepatocellular Carcinoma to Gemcitabine By Non-Invasive Radiofrequency Field-Induced Hyperthermia
<p>Gemcitabine is a potent nucleoside analogue against solid tumors however drug resistance rapidly emerges. Removal of gemcitabine incorporated in the DNA by repair mechanisms could potentially contribute to resistance in chemo-refractory solid tumors. In this study, we evaluated homologous …
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The Role of Autophagy In The Sensitivity of Osteosarcoma Cells to Gemcitabine Treatment
… in our laboratory has demonstrated that aerosol gemcitabine (GCB) treatment has a significant therapeutic effect on metastatic OS. However, treatment efficacy is decreased due to acquired resistance by a population of tumor cells that fails to respond to treatment. Recent studies have implicated …
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The development and characterisation of MicroRNA and gemcitabine nanotherapies for the treatment of pancreatic cancer
… On the other hand, the bottleneck with using gemcitabine, the first line chemotherapeutic agent, is the rapidly developing resistance coupled with low bioavailability.<br/><br/>The aim of this project is to elucidate the potential role of miR-143, miR-145 and gemcitabine triphosphate in the …
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THE NOVEL GEMCITABINE PHOSPHOLIPID CONJUGATE KPC34 HAS ACTIVITY AGAINST MULTIPLE MODELS OF RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA
Acute leukemias are cancers of the blood and bone marrow that affect thousands of Americans annually. These diseases can be myeloid or lymphoid in origin. Common components of therapy for both types of disease involve cytarabine and an anthracycline. After initially responding to treatment, most …
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Untersuchung von Apoptosemechanismen an der Ovarialkarzinom-Zelllinie HEY nach einer dosis- und zeitabhängigen Behandlung mit Gemcitabine
… und mögliche Chemoresistenzen umgehen zu können. Gemcitabine, ein Nukleosidanalogon letzter Generation, hat sich als sehr wirksam und gut verträglich beim Ovarialkarzinom herausgestellt. Voruntersuchungen in unserem Labor zeigten an der Ovarialkarzinomzelllinie Hey, dass Gemcitabine zeit- und …
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Evaluation of nanoscale delivery of miR 216 a/b, miR 217, and gemcitabine in pancreatic cancer cell lines
… co-delivers miRNA-216a/b, miRNA-/217 and gemcitabine. In vitro studies on human (Capan-1, MIAPaCa) and murine (KCT-3248) pancreatic cancer cell lines revealed that DDND treatment significantly reduced cell viability, increased apoptosis, and impaired cell migration and colony formation, …
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Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile
<p>SYNERGISTIC EFFECTS OF GARCINOL AND GEMCITABINE IN ENHANCING THERAPEUTIC EFFICACY IN PANCREATIC ADENOCARCINOMA CELLS AND ITS EFFECT ON MICRORNA PROFILE</p> <p>By</p> <p>MANSI PARASRAMKA</p> <p>ADVISOR: DR. SMITI V. GUPTA</p> <p>MAJOR: NUTRITION AND FOOD SCIENCE</p> <p>DEGREE: DOCTOR OF …
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Development and In-Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma
… long circulating liposomes for the delivery of gemcitabine and irinotecan hydrochloride in pancreatic cancer.|A simple HPLC method was developed for simultaneous quantification of gemcitabine and irinotecan in aqueous medium. The accuracy (% error < 10%) and precision (% RSD < 5%) of the methods …
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Investigations of the inhibition mechanisms of human ribonucleotide reductase by gemcitabine-5'-diphosphate and saccharomyces cerevisiae ribonucleotide reductase by Sml1
… and likely plays some role in DNA repair. Gemcitabine (2',2'-difluoro-2'-deoxycytidine, F2C) is used clinically in a variety of cancer treatments and the phosphorylated F2C targets many enzymes involved in nucleotide metabolism, including RNR. The studies presented here with [1 '-3H]- and …
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Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
… evaluating mechanistically a coculture model of gemcitabine resistance, established previously. I demonstrated that the gemcitabine resistance observed in coculture was a product of cell-cell contact, transient in nature, and related to cell density-mediated signalling processes. I discovered …
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Efforts towards the synthesis of fully N-differentiated heparin-like glycosaminoglycans; and, Investigations into the mechanism of inactivation of RTPR by gemcitabine triphosphate
Efforts towards the Synthesis of Fully N-Differentiated Heparin-like Glycosaminoglycans. Heparin-like glycosaminoglycans (HLGAGs) are complex information-carrying biopolymers and are an important component of the coagulation cascade. They have also been implicated in interactions with growth …
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Preparation and characterization of multifunctional chitosan microparticles for lung delivery
… system containing iron oxide nanoparticles and gemcitabine as the chemotherapeutic agent. Iron oxide nanoparticles were prepared by chemical co-precipitation. The iron oxide nanoparticles were made water dispersible by adding an oleic acid-poloxamer coat to the surface of the iron oxide …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… in conjunction with the chemotherapeutic agent, Gemcitabine. Using publicly available datasets, we first demonstrated that upregulation of PLAU, the gene encoding uPA, is associated with poor prognosis and aggressive phenotypes. This upregulation is particularly prominent in the basal subtype of …
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Application of pharmaceutical technologies to improve the activity of cancer chemotherapeutic agents
… to the Tween 80-based docetaxel formulation. Gemcitabine (2̕, 2̕-difluorodeoxycytidine, dFdC) is the first line treatment for advanced pancreatic cancer. It is also used in other cancers (e.g. ovarian and breast cancers). In this dissertation, docosahexaenoic acid (DHA), an omega-3 …
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PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
… PTEN-Long treatment alone or in combination with gemcitabine in the KPC model. To our surprise PTEN-Long preformed equivalently to gemcitabine as a monotherapy, and the animals had a significantly increased survival when treated with the PTEN-Long/gemcitabine combination. Further studies are …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… fewer metastases and higher sensitivity to gemcitabine treatment compared to AXL wild-type (WT) PDA mice. AXL-deficient PDA displays a more differentiated histology, lower equilibrative nucleoside transporter 1 expression and has a more inflammatory and active immune microenvironment, all of …
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