Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"GEFs"”.
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
Rac-GEFs (guanine-nucleotide exchange factors) are proteins that activate Rac GTPases, thereby enabling Rac-dependent cytoskeletal dynamics and cellular processes such as adhesion and migration. I used mice with genetically modified Rac-GEFs to identify new functional roles of these proteins in two …
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Determining the differential roles of the dock family of GEFs in drosophila development
… guanine nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell motility) proteins, Dock-ELMO complexes activate the Rho family of small GTPases to mediate a diverse array of biological processes, including cell motility, apoptotic cell clearance, and axon …
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Prime Editing as a Potential Therapeutic Intervention for Generalized Epilepsy with Febrile Seizures Plus (GEFS+): From Gene Editing to Functional Recovery
… Generalized Epilepsy with Febrile Seizures Plus (GEFS+), a severe neurodevelopmental disorder characterized by hyperthermia-induced seizures and premature mortality. Using an intein-split prime editor delivered via neuron-specific adeno-associated viral vectors (AAV-PHP.eB), we targeted the …
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Toward better subseasonal-to-seasonal prediction: physics-oriented model evaluation and predictability of tropical cyclones
… (NCEP) Global Ensemble Forecasting System (GEFS) with forecast lead time up to 2 weeks. It shows that the GEFS has large errors of TCs on the regional scale. The negative genesis biases over the western North Pacific are associated with a weaker-than-observed monsoon trough, the erroneous …
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Regulation of septum formation by RHO4 GTPase signalling in Neurospora crassa
… die zwei Guaninnukleotid-Austauschfaktoren (GEFs) BUD3 und RGF3 identifiziert, die nach ihren Homologen Bud3p und Rgf3p in Saccharomyces cerevisiae und Schizosaccharomyces pombe benannt wurden. Mittels in vitro GEF-Assays wurde gezeigt, dass beide Proteine spezifisch die …
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Analysis of uncertainty in hydrometeorological ensemble forecasts
… downscaled NOAA Global Ensemble Forecast System (GEFS) meteorological forcings for the 2016-2017 wet season (October-March) in California to create an 11-member hydrologic forecast ensemble. To evaluate the performance of these ensemble forecasts, we chose to study streamflow sites within Sonoma …
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Integrated regional enstrophy and its correlation with regime transitions in the Northern Hemisphere
… for the Global Ensemble Forecasting System (GEFS) (on a 1[degrees] 1[degrees] latitude-longitude grid) provided by the National Oceanic and Atmospheric Administration (NOAA) Weather Prediction Center (WPC) and the National Centers for Environmental Prediction / NOAA reanalysis (on a …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing evidence suggests that BDNF/TrkB …
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Maximising Board governance effectiveness in small and medium-sized Australian independent schools
… seven governance effectiveness factors (GEFs) from the literature on governance in schools and other non-profit organisations. These factors were used as assessment instruments in seven case studies of school boards in small to medium-sized independent schools. The research was …
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Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
… for mediators of cell invasion. A number of GEFs have been shown to regulate the invasive phenotype of tumours and cancer cell lines, leading to the hypothesis that P-Rex1 is an invasion promoting gene. We show that overexpression of P-Rex1 induces dramatic morphological changes in …
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Substratspezifität der nicht-dbl-homologen G-Nukleotid-Austauschfaktoren SopE und SopE2 aus Salmonella typhimurium
… sich, dass SopE eine von der Struktur zellulärer GEFs unabhängige Lösung gefunden hat, den Nukleotidaustausch an RhoGTPasen zu katalysieren. In einer Mutagenesestudie konnten diejenigen Aminosäuren identifiziert werden, die das katalytische Zentrum von SopE bilden. Die Ergebnisse dieser Arbeit …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… membrane-associated guanine exchange factors (GEFs), and inactive when bound to guanosine diphosphate (GDP). RhoA, a member of the Rho family GTPases, participates in the formation of focal adhesions, retraction of neuron processes in response to injury or insult and growth cone collapse. Rac1, …
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The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42
… (GAPs) and Guanine Nucleotide Exchange Factors (GEFs). GAPs accelerate the intrinsic catalytic activity of the GTPase to physiologically relevant levels and lead to the rapid inactivation of a GTPase. GEFs conformationally eject bound GDP from inactivated GTPases allowing the binding of GTP and …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 (Net1) is a Rho GEF specific for the RhoA subfamily that is overexpressed in primary breast tumors and breast cancer cell lines. Net1 isoform expression is also required for migration and invasion of …
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The Arf GTPase exchange factor Sec7p interaction network:
… it’s relationship to the other yeast Golgi Arf-GEFs. Arf proteins and their regulators play an important role in the formation of vesicles at the exit from the Golgi apparatus. There are three Golgi-localized Arf-GEFs in S.cerevisiae, Sec7p and the redundant Gea1p/Gea2p. While it has been …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
… of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. P-Rex1 …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… or off" states, respectively. It is thought that GEFs and GAPs function as intracellular mediators between transmembrane receptors and RhoGTPases to regulate cytoskeletal rearrangements. During my dissertation I identified the GAP α2-chimaerin as an essential downstream effector of the axon …
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by stabilizing the nucleotide-free state of the GTPases via their DH/PH domains; this facilitates binding of GTP and activation of the protein. The RGS subfamily of RhoGEFs (RGS-RhoGEFs) act as …
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The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission
… Maße im Hippocampus exprimiert. Viele andere GEFs und auch GTPase aktivierende Proteine (GAPs), die Ras Proteine regulieren, wurden schon auf ihre neuronale Funktion hin untersucht. Im Gegensatz dazu wurde die Funktion von Rasgrp1 bis jetzt noch nicht erforscht. Die Ergebnisse meiner Studie …
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
P-Rex guanine-nucleotide exchange factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, …
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