Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"GEF"”.
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Ric-8: un nuevo GEF con estructura tipo "armadillo"
… possess guanine nucleotide exchange activity (GEF) on heterotrimeric G-proteins, but with different Gα subunits specificities. To gain insight on the mechanisms involved in RIC-8 cellular functions it is essential to obtain some information about its structure. Therefore, the aim of this thesis …
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
P-Rex guanine-nucleotide exchange factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, …
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Regulatory domains of the Arf GEF Sec7 scaffold autoinhibited and active conformations
… modification following its activation by the Arf GEF Sec7. A network of inter- and intramolecular interactions of Sec7 gives robust spatiotemporal specificity to the potent Arf GEF. The Sec7 homodimer is autoinhibited, and interactions with Rab1, Rab11, Arl1, Arf1 and the membrane recruit Sec7 and …
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R-RAS41A fusion protein purification and the cloning of a new RAS GEF like gene
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Immunhistochemische und funktionelle Analyse der Interaktion des neuronalen K+Cl--Kotransporters KCC2 mit dem GEF-Protein βPIX
… der Interaktion zwischen KCC2 und dem GEF-Protein βPIX. Immunhistochemische Kolokalisationsanalysen in Hippocampus und Cerebellum lieferten starke Hinweise auf eine Regulation der KCC2-Transportaktivität durch βPIX. Diese Hypothese konnte im Rahmen radioaktiver …
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Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
… is a guanine-nucleotide exchange factor (Rac-GEF) for the small GTPase Rac, recognised for its involvement in neutrophil migration and ROS generation in response to GPCR activation—functions traditionally attributed to its Rac-GEF activity. Additionally, previous findings from our laboratory …
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Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
… (EGFR), EGFR targeted inhibitors, such as gefitinib (GEF), have yet to demonstrate efficacy. Using mass spectrometry to identify pathways that remain activated in the presence of GEF, we found that components of the mTOR signaling pathway remain phosphorylated. While inhibiting mTOR with …
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At the Confluence: Participatory Development, State-Society Relations, and Transboundary Water Management in the Kura River Basin
… described by the Global Environment Facility (GEF), a large multilateral financial mechanism promoting international cooperation on global environmental protection, as critical to the longevity and impact of projects related to the management of international waters. Public participation is …
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China's Participation in the South China Sea Environmental Project: Moving From a Laggard to a Leader in the Regional Environmental Cooperation
… Programme (UNEP)/Global Environmental Facility (GEF) South China Sea Project in 1999 marked a dramatic attitude change by the Chinese government towards the South China Sea environmental protection. It is the first multilateral inter-governmental initiative signed by China on any issues related …
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The Assembly of Pathogenic Signaling Circuits by a Family of Bacterial Secreted Effector Proteins
… as a guanine-nucleotide exchange factor (GEF) for Rho family GTPases. Using a structure to function approach, we uncover a GEF-GTPase pairing mechanism important for signaling fidelity and pathogenic diversity. Guided by these structural insights, we next wanted to know how E. coli, an …
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Sleep and neuropsychological functioning in school aged children
… demonstrated that global executive function (GEF) was significantly lower in healthy children with higher sleep disturbance. Sleep disturbance was not associated with individual performance on executive function tasks.<br/>The second study also examined sleep and executive function in healthy …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
… of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. P-Rex1 …
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
Rac-GEFs (guanine-nucleotide exchange factors) are proteins that activate Rac GTPases, thereby enabling Rac-dependent cytoskeletal dynamics and cellular processes such as adhesion and migration. I used mice with genetically modified Rac-GEFs to identify new functional roles of these proteins in two …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… Rho-family GTP exchange factor (GEF) Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent …
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The Arf GTPase exchange factor Sec7p interaction network:
… new physical interactors of the late Golgi Arf-GEF Sec7p: the lipid kinase Pik1p and the cyclic nucleotide phosphodiesterase Cpd1p. In addition, our studies on the function of Sec7p revealed additional feature of this protein and it’s relationship to the other yeast Golgi Arf-GEFs. Arf proteins …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… between Rho GTPases and the upstream activation GEF (Guanine nucleotide exchange factor) proteins. Therefore, in this research I have identified a lead molecule that could be used to develop inhibitors against <i>Af</i>Rho1 and <i>Hs</i>RhoA by inhibiting the corresponding GEF proteins mediated …
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The P-Rex1 Regulator Norbin Suppressess Neutrophil-Dependent Antibacterial Immunity
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein Rac, thus regulating a wide range of physiological and pathophysiological responses. Neutrophils are leukocytes of the innate immune system in which P-Rex1 regulates several Rac-dependent responses, especially …
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Charakterisierung der funktionalen Rolle von Cytohesin-1 in der LFA-1-vermittelten T-Zell-Adhäsion
… die Guaninnukleotid-Austauschfunktion (GEF-Funktion) von Cytohesin-1, da die GEF-defekte Punktmutante, Cytohesin-1(E157K), nicht mehr in der Lage war, die Adhäsion von Jurkat E6-Zellen an ICAM-1 stabil zu induzieren. Biochemische Interaktionsstudien konnten dabei zeigen, daß die Mutante …
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Rho GTPases and their regulators in cell polarity of the filamentous ascomycete Neurospora crassa
… Rho-Guaninnukleotid-Austauschfaktoren (RhoGEFs) und Rho-GTPase-aktivierende Proteine (RhoGAPs) beschleunigen die Bindung von Nukleotiden bzw. deren Hydrolyse durch Rho-GTPasen und bestimmen, wie zunehmend deutlich wird, in erheblichem Maß das räumliche und zeitliche Aktivitätsmuster von …
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P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis
… identified a PTEN interacting protein, the Rac GEF P-REX2, which inhibits PTEN phosphatase activity in a non-competitive manner. This thesis focuses on understanding the physiological relevance of this interaction in the regulation of PI3K signaling, as well as determining the mechanism of …
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