Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"GDNF"”.
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Characterisation of Prodomains in the GDNF Family
… the glial cell line derived neurotrophic factor (GDNF) family, both GDF15 and NRTN signal through the RET receptor. RET signalling is essential in normal development and is facilitated by a distinct co-receptor for each GDNF family member. NRTN was originally identified as a neurotrophic factor …
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Expression and function of GDNF family ligands and their receptors by human immune cells
GDNF (glial cell line-derived neurotrophic factor) und NTN (Neurturin), die zwei zuerst beschriebenen Liganden der GDNF-Familie, fungieren als Überlebens- und Entwicklungsfaktoren für definierte Populationen von zentralen und peripheren Neuronen. GDNF ist darüber hinaus für die Nierenentwicklung …
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Cloning of medaka glial cell-derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
Glial cell line-derived neurotrophic factor (GDNF) signaling through its receptor GFRI?1 plays an important role in many biological processes including cell survival, proliferation and differentiation. The aim of this project was to isolate and characterize both Gdnf and GfrI?1 from the medaka fish …
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Einfluss des GDNF-Rezeptors Ret auf die Erholung des nigrostriatalen Systems im MPTP-Mausmodell der Parkinsonerkrankung
… den Glial cell line-derived neurotrophic factor (GDNF) wurde als wichtiger Differenzierungs- und Überlebensfaktor für dopaminerge Neurone des Mittelhirns in vorklinischen Experimenten identifiziert. Diese positiven Ergebnisse führten zu klinischen Versuchen mit GDNF, welche in widersprüchlichen …
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Towards Gene Therapy of Parkinson’s Disease: Implantation of RUC-GDNF Secreting Mammalian Cell Lines into Rat Brain
… cell line derived neurotrophic factor (RUC-GDNF) fusion protein in CSF. The RUC-GDNF protein is expected to report GDNF secreted from the cell by bioluminescence through luciferase activity.</p> <p>Current <em>ex vivo</em> gene therapy using GDNF is limited by lack of a monitoring mechanism …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… glial cell line-derived neurotrophic factor (GDNF) has been implicated in promoting postnatal regenerative processes in the ENS. It has been proposed that intestinal smooth muscle cells (ISMC) express GDNF as a precursor molecule that requires proteolytic processing to achieve the mature form …
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Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
… Der glial cell line-derived neurotrophic factor (GDNF) ist in präklinischen Studien als wichtiger Differenzierungs- und Überlebensfaktor für dopaminerge Neurone des Mittelhirnes identifiziert worden, jedoch hat seine Anwendung in klinischen Studien inkonistente Wirkung gezeigt. Aktuelle …
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The glial cell line-derived neurotrophic factor family in the olfactory system and brain
Glial cell line-derived neurotrophic factor (GDNF) family signaling has been implicated in development, survival and function of many different cell types, including neurons in the central nervous system. The family consists of four ligands [GDNF, neurturin (NTN), artemin and persephin] which bind …
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Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering
… for Glial Cell-Derived Neurotrophic Factor (GDNF); hence to provide a local, long-term release and overexpression of GDNF via transfection of cells seeded into the scaffold or endogenous cells. The first part of the thesis aimed to investigate the in vitro transfection of marrow stromal stem …
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Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… the release of glial-derived growth factor: GDNF) and promoted neurite extension in vitro. The efficacy of the ABDS and GDNF in vivo to promote nerve regeneration in a rat sciatic nerve critical defect was determined through histomorphometric outcomes. Histomorphometric measures revealed that …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… production glial-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Therefore, the aim of these studies was to determine the involvement of OPN and an RGD containing peptide in the regulation of glia and neurotrophic factors in the neuroprotective properties of OPN …
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The Role of ERK5 in Dopamine Neuronal Survival
… the glial cell line-derived neurotrophic factor (GDNF) or dopamine neuron stimulating peptide-11 (DNSP-11) did not protect human dopaminergic SH-SY5Y cells against 6-hydroxydopamine (6-OHDA)-induced toxicity at 24 h. However, GDNF or DNSP-11 pretreatment protected against 6-OHDA-induced increase …
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Growth factors in extraocular muscles: effects on contractile properties
… Growth Factor 1), CT1 (Cardiotrophin 1), and GDNF (Glial-cell line derived neurotrophic factor), on contractile properties of extraocular muscles, and I provide evidence that these growth factors regulate development and plasticity of extraocular muscles. In the first project, I tested the …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… Glial cell line-derived neurotrophic factor (GDNF), which has been demonstrated to be the most potent neurotrophic factor for the proliferation, differentiation, and survival of spinal motor neurons, exhibits very good therapeutic potential for ALS. MSCs were infected with recombinant …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
… neurocan. Finally, inducible expression of GDNF and ChABC from transplanted NPCs in DCM has the potential to improve graft survival and integration, while providing neuroprotective and regenerative benefits for host cells. Therefore, a dual safe-harbour tetracycline-inducible control system …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… glial cell line-derived neurotrophic factor (GDNF) and HIF1-α have both been demonstrated to be neuroprotective during metabolic inhibition. In co-cultures, GDNF was observed to prevent neuron loss by an ETC uncoupler or glucose deprivation. Hypoxic preconditioning also protected against …
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Regulation der Capsaicin-Sensitivität von murinen Spinalganglienzellen durch neurotrophe Faktoren
… Zum anderen konnte gezeigt werden, dass GDNF dosisabhängig den Anteil der Neurone mit Capsaicin-induziertem Cobalt-Uptake reguliert und dosisabhängig parallel in zwei Gruppen von Spinalganglienzellen den Cobalt-Uptake induziert: einerseits über den GDNF-Rezeptor GFRa2 und die …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… rationally-designed isoquinuclidines that induce GDNF production by brain cell models. In addition to examining the mechanism of action of an isoquinuclidine (XL-026) using pharmacological inhibition, the mapping of GDNF production and release by C6 rat glioma cells is described and a mechanistic …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… release of Glial Derived Neurotrophic Factor (GDNF) from a model astroglial cell line. Part I consists of Chapters 1-5. Chapter 1 provides a brief introduction to the relationship between chemistry and neuroscience, while explaining the motivation and background behind the development and study …
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