Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"GDF5"”.
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Growth Differentiation Factor 5 is a Paracrine Regulator of Sarcopenic Obesity
… maintenance in those with SO. Specifically, Gdf5, has been recognized as playing a part in Bone Morphogenic Protein signaling to activate protein synthesis and deactivate protein degradation via SMAD 1/5/8 and SMAD 4 complex. Using RNA sequencing, Gdf5 was identified as being significantly …
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Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
… evaluate the molecular mediators through which GDF5 promotes neurite growth in cellular models of PD. GDF5 is known to mediate its neurotrophic growth factor effects by regulating the BMP-Smad signalling pathway. Therefore, for GDF5 to be a suitable candidate therapy for PD, it is important that …
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Preclinical evaluation of a novel AAV-GDF5 vector in a 6-OHDA model of Parkinson’s disease and evaluation of the effect of 6-OHDA on the expression of HDACs
… this study, we used an AAV2/5 vector to deliver GDF5 to the substantia nigra of rats, both at the same time as striatal administration of 6-OHDA and two weeks prior to 6-OHDA administration. We found that those animals which received AAV2/5-GDF5 had similar levels of TH immunopositive cell body …
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Genetic and epigenetic variation within extracellular matrix genes as risk factors for human tendinopathy
… that gene variants within the TNC, COL5A1, MMP3, GDF5 and CASP8 were associated with ATP in a Caucasian Australian and South African population. Furthermore, epigenetic mechanisms such as DNA methylation and microRNA (miRNA) activity have been implicated in a range of diseases but were never …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… regulated by HDAC5 and HDAC9. Both BMP2 and GDF5 have been identified as promising NTFs involved in DA neuronal development and capable of protecting against α-syn-induced degeneration. Therefore, we hypothesised that mechanistically, the inhibition of HDAC5 and HDAC9 might offer protection …
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Middle ear development: Genetics and disease
… regulators of joint development and show<br/>Gdf5 misexpression in the Eya1 +/- middle ear. I suggest Eya1 indirectly regulates middle ear joint patterning through a more general role in cartilage development. During postnatal development, Eya1 may further be required for the maintenance of …