Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"GDF2"”.
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… as a therapy for PAH. Nonetheless, mutations in GDF2, which encodes BMP9, or BMP10 had not been conclusively associated with PAH. BMP9 and BMP10 are produced as inactive ProBMPs, which are processed by proteases to leave an active, non-covalent Pro:BMP complex of the prodomains and growth-factor …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
… in two new pertinent genes, namely KDR and GDF2. I found that patients harbouring protein-truncating variants in KDR showed mild fibrotic changes on high resolution computed tomography, which were further characterised as patchy bronchocentric fibrosis on wedge biopsy from one patient. GDF2 …
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Studying the Effect of TBX4 Loss-of-Function on Postnatal Lung Development and How it Predisposes to Pulmonary Hypertension
… signaling) and genes (Lgr5, Tnc, Wnt3a, Areg, Gdf2, and Bmper) relevant to lung alveologenesis, angiogenesis, and PH. This study contributes significant knowledge that clinicians can use to diagnose, classify, and treat patients with TBX4 mutations.