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Showing 1 to 10 of 10 for “"GDF15"”.
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The Role of Gdf15 In Ovarian Cancer
<p>Growth Differentiation Factor 15 (GDF15) is induced in situations such as stress, inflammation, treatment with non-steroidal anti-inflammatory drugs, as well as other therapeutic agents. As a secreted protein, GDF15 is seen as a potential biomarker in several types of cancer as well as in other …
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Characterisation of Prodomains in the GDNF Family
Growth Differentiation Factor 15 (GDF15) and Neurturin (NRTN) have wide ranging roles in biology, with potential applications in diseases such as diabetes and obesity. As members of the glial cell line derived neurotrophic factor (GDNF) family, both GDF15 and NRTN signal through the RET receptor. …
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Peptide Corrination for the Mitigation of Nausea and Emesis in the Treatment of Type 2 Diabetes
… use of GRASP a growth differentiation factor 15 (GDF15) glial derived neurotropic family receptor α-like (GFRAL) complex antagonist.</p>
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
… the expression of the anorexiogenic peptide GDF15 by a subset of kidney proximal tubule (PT) cells. Blocking this response with a GDF15 antibody alleviates cachexia in Adh5-/-Csbm/m mice. Therefore, CSB provides protection to the kidney and brain against DNA damage caused by endogenous …
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Low-grade aldehyde stress protects mice from diet-induced obesity
… challenges. This protection is mediated by GDF15, a hormone that is elevated in response to endogenous formaldehyde stress when DNA repair is intact and causes a decrease in food consumption during the dietary challenge. By genetically disrupting GDF15, I demonstrate that this hormone is …
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An interdisciplinary approach leveraging human genetic variation to identify novel mechanisms of liver disease and pregnancy sickness
… Finally, in an examination of the role of GDF15 (Growth Differentiation Factor-15) in hyperemesis gravidarum we used observational epidemiology and rare and common genetic association studies to delineate the consequences of pre-natal and antenatal elevations in GDF15 on hyperemesis …
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Common Pathophysiological Features of Charcot-Marie-Tooth Disease
… 1 (NCAM1) and growth differentiation factor 15 (GDF15) as serum biomarkers of CMT. NCAM1 may potentially function as a disease-progression biomarker, whereas GDF15 is indicated to be a very accurate diagnostic biomarker. Additionally, I find that broad elevation of serum complement proteins …
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The effects of metformin on the gastrointestinal tract
… collaboration, we demonstrated that Gdf15 upregulation in the distal small intestine and colon were associated with the weight loss effects of metformin. The results from transcriptomic analysis in this study identified Gdf15 as one of the most significantly upregulated genes in …
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… Also, expression of pro-angiogenic genes (ADM, GDF15, HMOX1, SERPE1 and SERPB8) was determined to be dependent on KDMs under hypoxia. Further, treating cells with a general KDM inhibitor blocked the induction of these pro-angiogenic genes. Expression of stem cell markers in hemangioblastomas was …
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Understanding and stratifying brain health through blood-based omics data
… 9, where I generate protein EpiScores for GDF15 and NT-proBNP, which are two leading cardiovascular disease (CVD) markers implicated in brain health. I use a much-expanded sample size (n ≥ 16,963) to train these scores and show that they replicate protein-disease associations and associate …