NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 8 of 8 for “"GDF-5"”.

  1. The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain

    O'Keeffe, Gerard W.University College Cork2004

    Growth differentiation factor-5 (GDF-5) is a member of the transforming growth factor-β superfamily, a family of proteins that play diverse roles in many aspects of cell growth, proliferation and differentiation. GDF-5 has also been shown to be a trophic factor for embryonic midbrain dopaminergic …

    cork Repository record

  2. Die osteoinduktive Potenz verschiedener gentechnisch modifizierter Bone Morphogenetic Proteins : Eine vergleichende Untersuchung im Rattenmodell

    Depprich, RitaUniversität Würzburg

    … geringere osteogene Potenz ließ sich sowohl bei GDF-5 als auch BMP-6 feststellen. Die Varianten GDF-5 Chimär (B2GDF-5) und BMP-2-6 (B2BMP-6), die jeweils die N-terminale Sequenz von BMP-2 bis Lysin 12 fusioniert mit GDF-5 bzw. BMP-6 enthalten, zeigten keine veränderte biologische Aktivität im …

    wurz-thes Repository record

  3. Struktur- und Funktionsanalysen an BMP Ligand-Rezeptor-Komplexen

    Keller, SaschaUniversität Würzburg

    … I Rezeptor Komplexen für BMP-2, BMP-6 und GDF-5, sowie die der ternären Komplexe von BMP-2, BR-IAec und ActR-IIec bzw. BR-IIec. Die extrazellulären Domänen der hierfür verwendeten Rezeptoren wurden durch Expression in E.coli oder Sf-9 Insektenzellen erhalten. Ihre funktionelle …

    wurz-thes Repository record

  4. Alternative strategies to incorporate biomolecules within electrospun meshes for tissue enginering

    Vaidya, Prasad AvdhutVirginia Tech2014

    … ligament-relevant biomolecules such as FGF-2 and GDF-5.

    vt Repository record

  5. The influence of collagen-GAG scaffold architectural and biological cues on tenocyte and mesenchymal stem cell bioactivity for musculoskeletal tissue engineering

    Caliari, Steven R.University of Illinois at Urbana-Champaign2013

    … biomolecules (SDF-1α, PDGF-BB, IGF-1, bFGF, and GDF-5) on the recruitment, proliferation, collagen synthesis, and genomic stability of tenocytes within anisotropic CG scaffolds. Chapter 4 uses selective modification of our standard CG scaffold to probe the combined influences of structural and …

    uiuc Repository record

  6. Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration

    Gadomski, StephenUniversity of Cambridge2023

    … SOX9<sup>+</sup> chondrospheroids with BMP-2 and GDF-5 produced uniform and stable expression of COL2A1, ACAN, and PRG4 and minimal expression of COL10A1 <i>in vitro</i> and <i>in vivo</i>. Osteochondral transplantation of day 35 chondrospheroids, which mimicked the transcriptional identity of a …

    cambridge Repository record

  7. Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease

    Anantha, JayanthUniversity College Cork2021

    … ongoing pursuit. Growth differentiation factor (GDF)5 is one such neurotrophic factor under consideration for PD therapy. Therefore, in this body of work, we evaluate the molecular mediators through which GDF5 promotes neurite growth in cellular models of PD. GDF5 is known to mediate its …

    cork Repository record

  8. Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease

    O'Mahony, AdamUniversity College Cork2025

    … (BMP)2 and Growth differentiation factor (GDF)5, respectively, given that they have been identified as being regulated by HDAC5 and HDAC9. Both BMP2 and GDF5 have been identified as promising NTFs involved in DA neuronal development and capable of protecting against α-syn-induced …

    cork Repository record