Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"GD2"”.
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Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment of Gd2 Positive Tumors
… on many tumors such as the ganglioside, GD2, can be conjugated to drug-loaded liposomes to create a targeted drug delivery system. In this study, we have encapsulated etoposide, a topoisomerase inhibitor effective against a wide range of cancers, in surface modified liposomes decorated …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most tumors and plays a role in tumor progression. Similarly, we have previously found GD3S to be significantly upregulated in GD2+ breast cancer stem cells (BCSC) compared to GD2- cells, and …
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Development of a canine model to evaluate CAR-T cell subsets
… We hypothesized that the disialoganglioside GD2 would be a viable CAR tumor target in canine osteosarcoma (OS). The primary CAR used in these studies was a GD2 directed CAR which is currently undergoing human clinical trials. Using the same antibody clone from which the GD2 CAR is derived, we …
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DISORDERING IN PYROCHLORE PHASES FOR RADIONUCLIDES DISPOSAL: A MULTISCALE STRUCTURE STUDY
… the field of radionuclides immobilization. The Gd2Zr2O7 composition, in particular, has demonstrated high radiation resistance, making it an ideal host-matrix for encapsulating radioactive elements within the crystal structure. Despite the average structure, chemical composition can induce …
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Computational Study of the Properties and Stabilities of Endohedral Metallofullerenes
… for two newly discovered EMFs, Y2C2@C92 and Gd2@C79N. Y2C2@C92 is reported to exhibit a previously undiscovered mode of internal cluster rotation, while Gd2@C79N is shown to have unusual stability for an azofullerene with a large spin quantum number (15/2). Finally, computational techniques …
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Yttrium, Gadolinium, and Lutetium Based Endohedral Metallofullerenes: From Synthesis to Application
… room-temperature radical heterometallofullerene Gd2@C79N, and the egg-shaped TNT EMF Gd3N@C84. The reactivity of Gd2@C79N is directly compared to Y2@C79N, Gd3N@C80 and Sc3N@C80 in two reactions and the paramagnetic Gd2@C79N is proven to be very inert toward many known common fullerene cage …
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Platin und Palladium mit und in komplexen Anionen
… liefert das Lanthanoid-Platin(III)-Sulfat Gd2[Pt2(SO4)4(HSO4)2](HSO4)2, in dem erstmalig das [Pt2(SO4)4(HSO4)2]4--Anion beobachtet wird, welches die für Pt3+-Ionen typische Pt26+-Hantel enthält. Bei der Umsetzung von elementarem Palladium mit Selensäure kann in Abhängigkeit von den …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… a common childhood cancer, approval of anti-GD2 immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating mutations and amplification has provided hope to further increase of patient survival. Despite this success and that of precision …
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
… antibodies targeting the disialoganglioside GD2 have extended survival in neuroblastoma, relapse remains common. Thus, there remains a critical need for discovery of new immunotherapeutic targets. ALCAM is a cell-surface cell adhesion protein that is more highly expressed in neuroblastoma …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… leading to inhibition of gangliosides GD3 and GD2. GD3 is an abundantly expressed melanoma cell surface antigen with pivotal roles in cancer progression and invasion. OSW-1 promoted interaction between GD3 and mitochondrial voltage-dependent gating protein 1 (VDAC1). Subsequent VDAC1 activation …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… solid tumours by studying the potency of anti-GD2 re-directed Natural Killer (GD2NK) and T cells (GD2T) targeting neuroblastoma spheroids with time-lapse imaging. Flow cytometry studies show that at least 90% of CD19+ leukaemia cells were killed at high effector to target ratios (E:T=10:1), …
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Analysis of Inbreeding in a Closed Population of Crossbred Sheep
… additional measures of genetic diversity (GD₁, GD2). In order to estimate the diversity available in S and G, three sets of animals from the end of the study and one set of animals at line formation were considered in each line: all lambs born (including dead lambs), all matings (including …
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Precision Cytokine Therapy: Engineering and Delivery of CD8- and CAR-Tropic Interleukin-2 Variants
Glioblastoma is the most aggressive form of brain cancer, with median survival rates of less than 15 months. As the current standard of care is not curative, there is an urgent need to develop novel therapeutic approaches. Immunotherapy represents one potential strategy, although the unique …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… LRRs 9-12. Using this library, the epitope of GD2.F4, an inhibitory anti-TLR1 mAb, was mapped to amino acid residues located in the flexible loop of LRR11. Additionally, the amino acids F314, P315, Q316 and V339, within LRRs 11 and 12, were each found to be necessary for the sensing of …