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Showing 1 to 14 of 14 for “"GCV"”.
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Design Tool for a Ground-Coupled Ventilation System
Ground-coupled ventilation (GCV) is a system that exchanges heat with the soil. Because ground temperatures are relatively higher during the cold season and lower during the hot season, the system takes advantage of this natural phenomenon. This research focused on designing a ground-coupled …
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Molekulare Mechanismen des Tumorzelltodes induziert durch die Suizidgene Thymidinkinase und Purinnukleosidphosphorylase
… rpes-simplex-Virus-Thymidinkinase/Ganciclovir (TK/GCV)-System. Um die molekularen Mechanismen des PNP/Fludarabin-induzierten Zelltods in humanen HCC-Zellen im Vergleich zu TK/GCV zu untersuchen, wurden humane HCC-Zellen der Zellinien HepG2 und Hep3B mit PNP oder TK über adenovirale Vektoren …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… idoxuridine (IDU), and vidarabine, ganciclovir (GCV) gel and acyclovir (ACV) ointments. Some of the problems associated with thymidine analogues are their ocular and systemic toxicities in long term usage. Even though GCV and ACV have good efficacies against HSV, their limited solubility, poor …
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Mechanisms of Cell Death Initiated in Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated with Ganciclovir and UCN-01
… in combination with the prodrug, ganciclovir (GCV), has shown great promise for the genetic therapy of many cancers, but most patients have had only a partial or minimal response to the therapy. After screening a panel of two drug combinations, our laboratory has shown that the combination of …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
… transfer with the pro-drug ganciclovir (GCV) to be a promising suicide gene therapy in cancer. Unlike several other gene therapy systems, early-phase clinical trials of this strategy have shown encouraging results. Therefore, methods to improve its therapeutic efficacy are urgently …
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
… HS-tk gene effectively conferred ganciclovir (GCV) susceptibility to transduced cells. Each cell line showed a bystander effect (whereby wild type tumor cells are killed by co-incubation with HS-tk positive tumor cells and GCV). MNNG cells were used to develop a series of experiments in athymic …
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Untersuchungen zu Mechanismen der Triomzell-induzierten Tumorabstoßung
… Das Prinzip der Suizidgentherapie mit dem HSV-tk/GCV-System beruht auf der Transduktion des HSV-tk-Gens in Tumorzellen, die dadurch gezielt durch GCV abgetötet werden können. Dabei werden auch nicht-transduzierte, angrenzende Zellen miterfasst („Bystander“-Effekt). Ganciclovirsensible, …
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Development of a Lentivirus-mediated Gene Therapy Targeting HIV-1 RNA to Eliminate Infected Cells
… mRNA. HSVtk activates the prodrug ganciclovir (GCV), with cytotoxic metabolite GCV-triphosphate (TP) disrupting DNA synthesis to selectively kill HIV-1-expressing cells. Following proof-of-principle transfection studies, therapeutic constructs were engineered for lentivirus-mediated delivery to …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… of dipeptide monoester prodrugs of ganciclovir (GCV) including L-Val-L-Val-GCV (LLGCV), L-Val-D-Val-GCV (LDGCV), D-Val-L-Val-GCV (DLGCV) were formulated and dispersed in thermosensitive PLGA-PEG-PLGA polymer gel for the treatment of herpes simplex virus type 1 (HSV-1) induced viral corneal …
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CFD Simulation Methodology for Ground-Coupled Ventilation System
… develop new designs. By using these CFD tools in GCV systems designing procedure, energy can be conserved and designs going to be improved. The main objective of this study is to find and develop a CFD modeling strategy for GCV systems. To accomplish this objective, a case study must be selected, …
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A general approach to develop and assess models estimating coal energy content
The gross calorific value (GCV) is an important property defining the energy content of fuels such as coal. Many industries require the GCVs to accurately quantify and report the energy efficiency of the operations. Unfortunately, measuring the GCVs of coal can be a time-consuming and expensive …
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Studies on lipoic acid metabolism
… enzyme system, the glycine cleavage system (GCV), is required for utilization of glycine as a nitrogen source. In E. coli, lipoic acid is assembled on the LDs from the eight-carbon fatty acid, octanoate, in two steps. First, an octanoyltransferase (LipB) transfers an octanoyl moiety from the …
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INVERSE METHOD FOR DETERMINING TEMPERATURE DISTRIBUTION IN MACHINING
… criterion, and generalized cross validation (GCV) criterion are introduced to determine the optimal regularization parameters. In these methods, the optimal regularization parameters are obtained by minimisation of the criterion function. Cubic interpolation is used to minimize the criterion …
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Lipoic acid protein ligases in Plasmodium spp.
… (KADH) and the glycine cleavage system (GCV). The KADH include the pyruvate dehydrogenase (PDH), branched chain alpha-keto acid dehydrogenase (BCDH) and alpha-ketoglutarate dehydrogenase (KGDH), which are an integral part for any cell's metabolism. In Plasmodium spp. the lipoic acid …