Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"GCGR"”.
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… can activate both GLP-1R and glucagon receptor (GCGR), which is struc- turally analogous to GLP-1R. Furthermore, GLP-1R, despite its very low expression in the mouse αTC1.6 cell line detected through semi-quantitative RT-PCR studies, is found to play a critical role in directly inhibiting …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… C-terminal regions of GLP1R, glucagon receptor (GCGR), secretin receptor (SCTR), and corticotropin-releasing factor receptor type 1 (CRF1) were therefore investigated. Whilst some effects were observed when GLP1R was mutated, in many cases these SNPs had little effect on signalling. However, …
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Activation mechanisms of non-class A G protein-coupled receptors
… (SMO), six class B1 GPCRs - Glucagon receptor (GCGR), Glucagon-like Peptide 1 receptor (GLP1R), Parathyroid Hormone 1 receptor (PTH1R), Secretin Receptor (SCTR) and Pituitary Adenylate Cyclase 1 receptor (PAC1R), and fungal Class D receptor STE2, using large-scale all atom unbiased molecular …
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
… Sucnr1 might antagonize the glucagon receptor (GCGR), the most abundant Gs-coupled GPCR expressed in hepatocytes. Initially, succinate infusion experiments and assessment of its effects on glucagon signaling in mouse liver appeared to support the possibility that succinate might antagonize …