Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"GBM"”.
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… environments utilizing an <em>in-vitro</em> GBM model. The data accumulated in this study determined that hypoxia correlates with relative expression levels of hypoxia inducible factors (HIFs) as well as GLUT1. HIF-1b and GLUT1 appear to have different expression levels in fibroblast cells …
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LIQUID BIOPSY IN GLIOBLASTOMA (GBM)CHARACTERIZATION OF PLASMA EXTRACELLULAR VESICLES CONCENTRATION, SIZE AND CARGO FOR NON-INVASIVE GBM DIAGNOSIS, MONITORING AND IDENTIFICATION OF CIRCULATING BIOMARKERS
Glioblastoma (GBM) is a highly aggressive brain tumor that presents extensive heterogeneity and high recurrence rates. Current diagnostic and monitoring approaches, primarily relying on MRI and tissue biopsies, have limitations. MRI sensitivity is limited, and tissue sampling is invasive and may …
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IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR
<p>Glioblastoma multiforme (GBM) is the most common form of malignant glioma, comprising 80% of all malignant gliomas. Recently, active Human Cytomegalovirus (HCMV) was identified in GBM cells, and has been a topic of debate concerning its role with tumor progression. This study used three …
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Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.
… survival rate, glioblastoma multiforme (GBM) is a very deadly disease with a poor prognosis. Therefore, a curative treatment is in high demand. Among the widely used anti-metabolites (Chemotherapeutic agents, CAs), each compound approved for human use by the Food and Drug Administration …
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Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors
… levels in <em>MTAP-</em>deleted primary human GBM tumors are not significantly higher compared to <em>MTAP</em>-intact tumors. This discrepancy is due to the secretion of MTA into the extracellular environment and its subsequent metabolism by stromal cells expressing MTAP. We also have …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… particular Ang2, in the invasive recurrence of GBM following anti-VEGF therapy and that targeting it in combination with anti-VEGF therapy could lead to improved outcomes. Supporting this idea, we were able to observe a dramatic decrease in the invasive phenotype after anti-VEGF treatment when …
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Measuring mass changes in single suspended and adherent cells, with applications to personalized medicine in Glioblastoma Multiforme (GBM)
… measurements for use in Glioblastoma Multiforme (GBM) patient-derived cell lines, exploring the heterogeneity between and within patient tumors, and validating the measurement as a predictor of drug susceptibility with response times on the order of 24 to 48 hours using an experimental MDM2 …
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DEVELOPING SURFACE-MODIFIED LANTHANIDE-DOPED NANOPARTICLES AS A BRAIN TUMOR THERANOSTICS
Glioblastoma (GBM), a grade IV astrocytoma is highly aggressive and lethal. Recently, nano-based systems were widely used in GBM studies because of the ability to traverse the blood-brain-barrier successfully. However, there are still several major challenges. Lanthanide-doped nanoparticles …
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The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
Glioblastoma (GBM) is an aggressive malignancy characterized by extensive intra and intertumoral heterogeneity. NAD+ is a crucial metabolite involved in energy production, redox balance, and DNA-damage repair, and its biosynthesis and consumption are elevated in GBM. This dissertation investigates …
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Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… malignant brain cancer glioblastoma multiforme (GBM) displays invasive growth behaviors that are major impediments to surgical resection and targeted therapies. Adhesion and signaling pathways that drive GBM cell invasion remain largely uncharacterized. Here we have utilized human GBM cell lines, …
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In vitro modelling of human glioblastoma migration and angiogenesis
Glioblastoma (GBM) invasion and angiogenesis are critical for the tumour's fast growth and recurrence. A significant limitation in the development of innovative anti-invasive and anti-angiogenic treatments is the lack of personalised in vitro experimental models to accurately recreate the …
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In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
Glioblastoma multiforme (GBM) is one of the most aggressive and lethal cancers with a poor prognosis. Advances in the treatment of GBM are limited due to several resistance mechanisms and limited drug delivery into the central nervous system (CNS) compartment by the blood-brain barrier (BBB) and by …
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Role of Ion Channels in Glioblastoma
Glioblastoma (GBM) accounts for the majority of astrocytic tumours and represents the most common primary brain cancer. Prognosis for patients is dismal even with aggressive treatment. Because of diffused GBM invasion throughout the brain, it is impossible for surgery to completely remove the …
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T Cell Exhaustion in Glioblastoma
<p>Glioblastoma (GBM) is the most common primary malignant brain tumor. Despite standard of care treatment GBM remains universally lethal, demonstrating a significant need for newer treatment strategies such as immunotherapy. Immune checkpoint blockade is a type of immunotherapy which seeks to …
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Development of an Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells with Chemical and Physical Stimuli
Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor. Even after patients undergo maximum and safe surgical resection followed by adjuvant chemotherapy and radiation therapy, residual GBM cells form secondary tumors which lead to poor survival times and prognoses for …
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Identification of Circulating MicroRNAs as Biomarkers in Glioblastoma
… and prognosis of glioblastoma mulitforme (GBM). This is the first report of miRNA expression based on the age and sex of GBM patients. GBM and non-cancerous control patients were grouped into age categories (20-39, 40-59 and 60+ years old) and gender. Initial analysis was performed using …
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
Glioblastoma (GBM) is the most common and lethal primary brain cancer in adults despite aggressive treatments with surgery and chemo-radiation. Advances in electrotherapeutics offer a foundation for developing new treatment modalities that exploit an innate vulnerability of glioblastoma (GBM). Low …
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
<p>Primary glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, with a median patient survival of only 15 months from the time of diagnosis. GBM is particularly challenging to treat due to its aggressive and invasive nature, and has proven resistant to therapeutic …
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The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression
Glioblastoma (GBM) is the most aggressive, fatal, yet most common tumour to affect the central nervous system in adults. With a median survival time of only 15 months following diagnosis, it is a disease of high morbidity and mortality. Immunotherapies have shown great promise in the treatment of …
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Influence of the 3D microenvironment on glioblastoma migration and drug response
<p>Glioblastoma (GBM) is a highly invasive brain cancer characterized by poor prognosis. Despite significant efforts by the basic and clinical research community our understanding of GBM progression and recurrence has been incremental. Improvements in therapeutic response have been dismal, and GBM …
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