Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"GATA4"”.
-
Effects of GATA4-targeted compounds in hypertrophic models of hypoplastic left heart syndrome cardiomyocytes
… sydämen kehityksessä yhdessä transkriptiotekijä GATA4:n kanssa. Tämä tekee näistä geeneistä kiehtovia tutkimuskohteita HLHS:ssä. Tämä tutkimus pyrkii selvittämään, miten HLHS-potilaista johdetut ihmisen monikykyisistä kantasoluista erilaistetut sydänlihassolut (hiPSC-sydänlihassolut) eroavat …
-
GENERATION OF FULL-LENGTH WILD-TYPE GATA4 PROTEIN AND CHARACTERIZATION OF ITS BINDING TO UNC-45 DOMAINS
… with other sarcomeric proteins, and degradation. GATA4 is an important transcription factor that regulates the expression of several cardiac muscle proteins, including myosin. A previous study demonstrated for the first time that SM UNC-45 (also known as UNC-45B) physically interacted with GATA4. …
-
Gata4 et Cdx2 sont des régulateurs transcriptionnels intestinaux du gène encodant la protéine sécrétoire de type lectine Pap1
Gata4 est un facteur de transcription exprimé par les entérocytes. Nos études ont démontré que Gata4 pouvait réguler l'expression de Pap1 chez le rat. Ce gène encode pour une protéine sécrétoire de type lectine impliquée dans le contrôle de la prolifération bactérienne. Puisqu'il a été démontré que …
-
Expression of DIO2 in the Porcine Ovary and the Granulosa Cells of Humans
… StAR mRNA is modulated by transcription factors GATA4 and GATA6. These GATA factors have been shown to regulate gene expression in the ovary. Using Stealth RNAi coupled with cDNA microarray analysis using Affymetrix Porcine Genome Arrays, our lab sought to identify genes altered by reduction of …
-
The genetics of atrial septal defect and patent foramen ovale
… that mutations in the ASD genes NKX2-5 and GATA4 may cause apparently sporadic ASD was tested by sequencing them in unrelated probands with ASD. In this study, 1/102 individuals with ASD had an NKX2-5 mutation, and 1/129 had a deletion of the GATA4 gene. The cardiac transcription factor …
-
The Role of UNC-45 in Heart Development and Human Breast Cancer
… muscle myosin II and transcription factor GATA4, facilitating the folding of those chaperone client proteins. The recessive loss-of-function mutation of UNC-45b produced embryonic lethality at E9.5, due to the failure of contracting heart and arrest of cardiac morphogenesis of right heart …
-
DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
… fibroblasts (HDFs) when working together with GATA4, MEF2C, TBX5, HAND2 and MYOCD (5F). HDFs-generated iCMs exhibited cardiac-like action potential and spontaneously contractility in-vitro. Importantly, SALL4, together with 5F, promotes adult human cardiac fibroblasts (aHCFs) into cardiac-like …
-
Molecular Regulation of Direct Cardiac Reprogramming
… to iCMs by cardiac transcription factors [Gata4, Hand2, Mef2c, and Tbx5 (GHMT)], we screened 192 protein kinases and discovered that Akt/protein kinase B dramatically accelerates and amplifies this process in three different types of fibroblasts (mouse embryo, adult cardiac, and tail tip). …
-
Identification of Drosophila heart-specific Cis-Regulatory Modules under Hox control
… in Congenital Heart Diseases (CHDs) (NKX2-5, GATA4 and TBX5). The Drosophila cardiac tube is linear and composed of a rostral portion named aorta and a caudal one called heart, distinguished by morphological and functional differences controlled by Hox genes, key regulators of axial …
-
Role of Sonic Hedgehog in Development of the Central Nervous System
… meso-endoderm lineage markers, Gsc, Sox17, and GATA4. The results suggest that Shh promotes neurogenesis in multiple ways: by inducing the neuroectodermal cells, by repressing non-neural cell fates, and by promoting differentiation of neurally committed progenitor cells into motor and …
-
The Role of Mga in the Survival of Pluripotent Cells During Peri-implantation Development
… of Nanog or Oct4, pluripotent cell markers, or Gata4, a primitive endoderm marker. Expression of Ornithine Decarboxylase (ODC), the rate-limiting enzyme in the synthesis of cellular polyamines, was identified as a possible cause of embryonic lethality based on a similar mutant phenotype as well …
-
GATA Like Protein-1: A Somatic Cell Factor Required for Normal Ovarian Development and Function
… by loss of regulated steroidogenesis through the GATA4-dependent transcriptional activation of StAR. These data imply that the somatic cell protein Glp-1 regulates 1) germ cell survival early in embryogenesis and 2) steroidogenesis through StAR promoter activation.
-
The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… homozygous CC. Molecular analysis shows that GATA4 favors binding at rs9921222 allele T to promote AXIN1 expression; in contrast, ERα prefers to bind at allele C to suppress the expression, resulting in more expression of AXIN1 in homozygous TT than homozygous CC. Functionally, the level of …
-
Multifunctional Regulators of Cardiac Disease and Development
… I also identify Yap as a coactivator of GATA4, a trascription factor that functions as a regulator of angiogenesis in the heart. Moreover, my studies on deletion of Yap in other tissues suggest the possible role of Yap as a global angiogenic factor. Collectively, these studies show that …
-
Investigation of Copy Number Variation in South African Patients with Congenital Heart Defects
… overlapping genes known to be causal for CHD (GATA4, TBX1, FLT4, CRKL, NSD1, and B3GAT3), and four CNVs encompassing candidate genes likely to play a role in the development of CHD (DGCR8, JARID2, KDM2A, and FSTL1). The CNVs were identified in nine unrelated individuals: five of the CNVs were …
-
Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
… to activate hypoblast genes such as GATA6 and GATA4. Taken together, these findings highlight clear context-dependent roles for WNT signalling which deserve further investigation in both human pluripotent stem cells and preimplantation embryos. I hypothesise that contrary to present viewpoints …
-
Dietary Supplementation of Omega-3 Fatty Acids Influences the Equine Maternal Uterine Environment and Embryonic Development
… cycle 3 and 4, relative transcript abundance of GATA4 and GATA6, markers of endoderm differentiation, along with GATA3 and ELF3, markers of trophectoderm differentiation were greater (P< 0.05) in embryos from LCPUFA supplemented mares (n=5), than controls (n=5). These results indicate that …
-
A Compendium of Genetic Drivers for Oesophageal Adenocarcinoma defines Prognostic and Therapeutic Biomarkers for use in the Clinic
… Indicators of poor prognosis (SMAD4 and GATA4) were verified in independent cohorts with significant predictive value. Over 50% of OACs contained sensitizing events for CDK4 and CDK6 inhibitors, which were highly correlated with clinically relevant sensitivity in a panel of OAC cell lines …
-
Investigation of a pancreatic derived progenitor cell population for use in regenerative medicine
… However, only Thy1.1 positive PDPCs express GATA4, Hepatocyte Nuclear Factor 3 beta (HNF3b) and αFP in an undifferentiated state.The Thy1.1 positive PDPCs exhibited bi-potentiality for differentiation into both pancreatic and hepatic cell types, both morphologically and by RT-PCR. Thy1.1 …