Global ETD Search
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Showing 1 to 2 of 2 for “"GATA3 Transcription Factor"”.
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… well as memory Th2 cell function. The Th2 master transcription factor GATA3, promotes its own expression through a positive regulatory loop, uncoupling the cell from the requirement of IL-4 signaling. IFN-α/β inhibits this process by inducing epigenetic modifications within the GATA3 locus that …
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
The activity of the transcription factor oestrogen receptor α (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. This subtype constitutes up to three-quarters of breast cancer cases, and treatments directly targeting ER are currently the standard of care. ER operates …