Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"GATA2"”.
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Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation.
<p>The transcription factor GATA2 is highly expressed in hematopoietic stem cells (HSCs) and is downregulated during differentiation. Overexpression of GATA2 is frequently observed in acute myeloid leukemia. In previous studies, enforced expression of GATA2 using a MSCV GATA2 retroviral vector …
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Characterization of Gene-by-Age Interaction and Gene-by-Gene Interaction In Coronary Artery Disease
… evidence. Specifically, we investigated GATA2 as a candidate gene transcription factor, and modeled the interaction with genome-wide SNPs. The genetic effects at interacting loci were modified by GATA2 genotype. Without taking GATA2 variants into account , no marginal main effects were …
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Determinants of GATA1-mediated gene regulation during erythroid maturation
… mechanism which facilitates the replacement of GATA2, a transcription factor expressed at earlier stages of hematopoiesis, by GATA1. We show that Fbw7, an ubiquitin ligase protein trans-activated by GATA1, targets GATA2 for proteosomal degradation, thus reducing its halflife and leading to more …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… der Differenzierung neuraler Zellen spielen, wie Gata2, Runx1, Id3 und Nedd9. Die nähere Untersuchung der Auswirkungen eines Funktionsverlustes der Zielgene Ctgf, Gata2, Runx1 und Nedd9 auf die TGF-β induzierte Neurogenese identifizierte Nedd9 als notwendige Signal-Komponente während dieses …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
… by anti-adipogenic transcrition factors such as GATA2, to divert preadipocytes as well as multipotent mesenchymal prescursors away from adipogenesis to osteogenesis. My study on the function of Hh signaling in fat formation of both invertebrates and vertebrates suggested that Hh signaling played …
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Paxillin-dependent control of tumor angiogenesis
… and this is mediated by the transcription factor GATA2. Direct knockdown of NRP2 also increases endothelial cell migration and vessel density in vitro and in vivo and these effects are rescued by over expressing paxillin. In summary, these studies have led to the discovery of a new mechanism for …
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… I have demonstrated that miR-194 is regulated by GATA2, an oncogenic transcription factor in PCa. On the other hand, my work demonstrated that miR-375 is a potent tumour suppressor miRNA, as it can inhibit EMT, invasion and growth of prostate cancer cells. I identified YAP1, a transcriptional …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… of IL-6 signalling suppresses expression of GATA2 and GATA3 and upregulates KLF4 transcripts. Finally, I investigate whether ablation of PKCι is sufficient to replace the activity of the PKC inhibitor, Gö6983. Established naïve cultures that are PKCι null continue to express naïve markers and …
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Mapping the transcriptional landscape of haematopoietic stem and progenitor cells
… progenitor network was identified, in which GATA2 positively regulated Nfe2 and Cbfa2t3h. This was subsequently validated using transcription factor binding profiles and in vitro luciferase assays using a model cell line. Overall, the work presented in this thesis confirmed known aspects of …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… pSTAT1, RUNX1, RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a model in which NFIX collaborates with PU.1 to regulate …
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Charting the single-cell transcriptional landscape of haematopoiesis
… positive regulation of Nfe2 and Cbfa2t3h by Gata2 that was unique to differentiation towards megakaryocyte-erythroid progenitors, which was subsequently experimentally validated. The next study focused on investigating the link between transcriptional and functional heterogeneity within blood …