Global ETD Search
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Showing 1 to 7 of 7 for “"GATA1"”.
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Determinants of GATA1-mediated gene regulation during erythroid maturation
… arise from progenitor cells. In this context, GATA1 is widely considered to be the master transcription factor for erythropoiesis, controlling the expression of a vast majority of the genes involved in red blood cell maturation. GATA1 dysfunction has been shown to cause several human disorders, …
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GATA1 Occupancy Site Regulates Erythroid Cell Fitness through Pleiotropic Functions
… of mutations disrupting transcription factor GATA1 binding sites. Our models achieve high predictive accuracy and reveal key regulatory features underlying these effects. However, we observed that a small subset of GATA1 binding sites with the most substantial functional effects are …
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Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
… harbor a mutation in the gene encoding the GATA1 transcription factor, resulting in the translation of a short-form protein GATA1s, which has been shown to contribute to chemotherapy sensitivity. In contrast, in non-DS patients, overexpression of GATA1 has been correlated with poorer …
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Tracing the evolution of lineage-specific transcription factor binding sites in a birth-death framework
… the ChIP-seq data for six transcription factors (GATA1, SOX2, CTCF, MYC, MAX, ETS1) along the lineage toward human after human-mouse common ancestor. We estimate that a substantial fraction of binding sites (∼58-79% for each factor) in humans have origins since the divergence with mouse. Over 15% …
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Transcriptional consequences of genetic variation on single cells in development and cancer
… resolution, and showed that TAM-defining GATA1 mutations account for most of the ML-DS transcriptome. Finally, I investigated the transcriptional features associated with progressive disease in ML-DS, leveraging alleleIntegrator to identify the cells responsible for refractory disease in a …
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REGULATION OF Fas-MEDIATED APOPTOSIS BY THE Fas ANTI-SENSE NON-CODING RNA "Saf"
… transcription factors KLF1 and GATA1. Chromatin immunoprecipitation (ChIP) assays confirmed binding of both factors to their target sequences and luciferase reporter constructs revealed synergistic activity evidenced by increase in luciferase expression relative to controls. …
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
<p>Terminal erythroid differentiation is a precisely regulated process, in which mature red blood cells are generated from late erythroid progenitor cells. Regulation of cellular proliferation, survival and differentiation determines the fate of those cells. Extracellular signaling molecule, …