Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"GATA-3"”.
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Die Interaktion der Transkriptionsfaktoren NF-ATc und GATA-3 in T-Helfer-Zellen
… anderem Bindestellen für NF-AT-Faktoren und GATA-3 auf. NF-ATc ist ein Mitglied der NF-AT („Nuclear Factor of Activated T-cells“)-Transkriptionsfaktoren, die an den verschiedensten immunologischen Funktionen beteiligt sind, vor allem aber an der Steuerung der Cytokingene. GATA-3 ist ein …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… concert with many transcription factors such as GATA-3 to fully induce this fate choice while inhibiting the B-cell lineage. Although both Notch and GATA-3 are indispensible for thymocyte development, their precise roles in directing these events remain to be elucidated. Examining such phenomena …
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Protein Kinase A regulates GATA-3 dependent Activation of IL-5 Gene Expression in T Helper Lymphocytes
… Konzentration des Transkriptionsfaktors GATA-3 zurückzuführen. So kommt GATA-3 in Th2-Zellen in hoher, in Th0-Zellen in geringerer und in Th1-Zellen in sehr geringer Konzentration vor. Die ektopische Expression von GATA-3 in Th1-Zellen induziert die Synthese Th2- typischer Lymphokine, die …
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Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… differentiation, we found that T-bet in Th1 or GATA-3 in Th2 cells could enhance, and NFATc2 could further synergize with either of them to increase, icos transcription via the icos promoter or a 3o "UTR element respectively. Finally, we also found that ICOS is controlled at a …
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Identifizierung und Charakterisierung von Kandidatengenen aus der DiGeorge Syndrom-Region auf dem kurzen Arm von Chromosom 10
… werden. In diese Region kartiert das Gen GATA-3. Mutationsanalysen in zytogenetisch normalen HDR-Patienten zeigten in drei Patienten Mutationen, die zu einem funktionslosen GATA-3-Protein führen. Damit wurde der Beweis erbracht, daß das HDR-Syndrom eine Einzelgenerkrankung ist und daß die …
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In vitro generation and programming of human CD8+ memory T cells
… naïve cells with IL-4 strongly upregulated GATA-3 expression following secondary stimulation, confirming that the programming we observed in this model was acting via transcription factors. Transcription factor expression profile of the in vitro-generated memory cells also confirmed an early …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… factor expression revealed higher expression of GATA-3 compared to T-bet and RORγt compared to Foxp3 suggesting a Th2 and Th17 skewed response. This suggests some division of labor among the DC subsets identified. Several studies have shown that CD11b+ DCs secrete a host of proinflammatory …