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Showing 1 to 8 of 8 for “"GATA-1"”.
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The role of GATA-1 isoforms in haematopoiesis
GATA-1 is a key haematopoietic transcription factor which plays a pivotal role in differentiation of the erythroid, megakaryocytic, eosinophilic, mast cell and dendritic cell lineages. Since its initial cloning and characterisation in 1989 a huge amount of information has been gathered on the …
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Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
… transporters expressed on the plasma membrane. GATA response element islands are present on the promoter of glioma lactate transporter genes, and GATA-1 has been shown to be over-expressed in glioblastoma. Our long-term goal is to inhibit glioma proliferation by indirectly down-regulating GATA-1 …
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Characterisation of two genetic loci involved in fetal haemoglobin production: BCLIIA and HBSIL-MYB intergenic region
… cells. In addition, we analysed binding of GATA-1 and KLF1, two major erythroid-specific transcription factors. Strong GATA-1 binding at the HMIP region coinciding with strong histone acetylation and RNA polymerase II activity was seen, indicative of the presence of regulatory elements in …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
… cells, I examined MAPK pathway and the role of GATA-1. I demonstrated that TGF-b mediated TIM-3 upregulation was inhibited both by a inhibitor of ERK but not by inhibitors of p38 and JNK. Further, overexpression of GATA-1 did not affect TIM-3 expression in HMC-1 cells. These results suggest that …
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The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression
… modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell mouse model leads to a decrease in the …
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Identification and Characterization of Control Elements within the Murine CD4 Gene
… sequences in the protected regions include GATA-1, Elf-1, and AP-1 for the 5' intronic enhancer, and PU.1, IRF-1, and GATA-1 for the 3' intronic enhancer. Among them, Elf-1 and PU.1, members of the Ets protein family, and AP-1 have been implicated in the regulation of T cell-specific gene …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… β-globin gene transcription; ii) lack of GATA-1 and NF-E2 recruitment to the β-globin promoter; iii) a block in terminal erythroid differentiation. In contrast to erythroid cells lacking EKLF, D221EKLF erythroid progenitors demonstrate appropriate binding of the D221EKLF encoding domain to …
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Influence of Insulin, Insulin-Like Growth Factor I and Sex Steroids On the Regulation of the Vitellogenin Receptor In Developing Oocytes of Largemouth Bass (Micropterus Salmoides)
… potential targets of hormone pathways including GATA-1 and ERE, among others. Functional promoter analysis studies revealed a primary role for <italic>esr1</italic> and <italic>esr2a</italic> in repressing <italic>vtgr</italic> transcription. The involvement of E<sub>2</sub> in downregulation of …