Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"GAP-43"”.
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nerd: A Neuron-Specific Gene in Drosophila Melanogaster Related to Vertebrate GAP-43
<p>The neuronal protein GAP-43 has been implicated in a number of key processes in neural development and synaptic behavior. There have been no reports identifying an invertebrate molecule with homology to GAP-43. In this study we have begun to explore the biochemistry and genetics of the …
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Quantifizierung von GAP-43 und die postnatale Entwicklung der molekularen Komplexität im auditorischen Hirnstamm der Ratte
… Veränderungen im Expressionsniveau von GAP-43 (Growth associated Protein 43) festgestellt werden. Die molekulare Komplexität steht dabei für die Gesamtzahl der detektierten Proteine und deren co- und posttranslationale Modifikationen. Aus deren Entwicklung über die Zeit lassen sich …
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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX
… for 5-HT, SERT, TPH, MAOA, VMAT2, SYP and GAP-43. Total brainstem levels of 5-HT and its metabolite 5-hydroxindole-3-acetic acid (5HIAA), were measured by HPLC. We found that Pb extends the normal developmental uptake of 5-HT by LSO neurons through prolonged expression of SERT. Total …
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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX
… for 5-HT, SERT, TPH, MAOA, VMAT2, SYP and GAP-43. Total brainstem levels of 5-HT and its metabolite 5-hydroxindole-3-acetic acid (5HIAA), were measured by HPLC. We found that Pb extends the normal developmental uptake of 5-HT by LSO neurons through prolonged expression of SERT. Total …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… of macrophages, Growth Associated Protein (GAP-43), and growth cones as detected through F-actin. The results show that GAP-43, which naturally increases expression during nerve regenerations is precociously activated days earlier than normal when CXB-NE is present. Furthermore, CXB-NE …
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Alterações do conteúdo de S100B durante o desenvolvimento em tecido encefálico, líquor e cultura de astrócitos corticais de rato
… Também foi avaliada a ontogenia da GFAP e GAP-43, dois possíveis alvos da S100B. Os resultados mostram um acúmulo de S100B em hipocampo, córtex cerebral e cerebelo entre a segunda e quarta semana pós-natal. Uma redução da S100B no líquor foi observada após um período considerado crítico …
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Regulation of filopodia dynamics is critical for proper synapse formation
… Indeed, the palmitoylated protein motifs of GAP-43 and paralemmin are sufficient to induce filopodial extensions in heterologous cells and to increase the number of filopodia and dendritic branches in neurons. We showed that the morphological changes induced by these FIMs (filopodia inducing …
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
… the transcriptional activation of genes such as GAP-43 and p21(CIP/WAF), known to be involved in the differentiation process. Collectively, our results unveil a functional link between the specific expression profile of neurotrophin receptors in neuronal cells and the NGF-mediated regulation of …
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The Role of Gene Regulation in Neural Circuit Development: Studies in the Zebra Finch
… control pathway. Three genes: canarigranin, GAP-43 and synelfin were tested, and changes in mRNA level were observed in all three cases, each at a specific song control nucleus. Behavioral isolations which delay the ""critical period"" for song learning did not delay the changes of the …
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Regulation of peripheral nerve regeneration by the mTOR pathway
… capacity in vitro and in vivo. We identified GAP-43 as a downstream target of this pathway, which may contribute to enhance regenerative ability. However, while genetic upregulation of mTOR activity in sensory neurons facilitates axonal regrowth, it also leads to a number of developmental and …
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Ciliary neurotrophic factor (CNTF) im olfaktorischen System von Ratten und Mäusen
… Kolokalisation mit dem Growth associated protein 43 (GAP-43) auf, dessen Expression unreife Riechsinneszellen kennzeichnet. CNTF könnte einerseits an lebenslang fortwährenden De- und/oder Regenerationsvorgängen des olfaktorischen Epithels beteiligt sein. Die Exposition der Riechschleimhaut …
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Dependencias tróficas y sinápticas del sistema oculomotor.
… la proteína asociada al crecimiento axonal de 43 kDa (GAP-43), que también se vio incrementada a corto plazo. De los resultados obtenidos se concluye que las motoneuronas oculomotoras deaferentadas mantienen una dependencia con los factores neurotróficos. Finalmente, se caracterizó mediante …
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Macrophage recruitment in DRG contributes to sensory axon regeneration after conditioning injury
… factors, regeneration associated genes (GAP-43) and oncomodulin at 7 days after CI. Furthermore, minocycline infusion reduced CI-induced neurite outgrowth in vitro and sensory axon regeneration after CI in vivo. These data suggest that macrophages play an essential role in the CI-induced …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
… expression of growth coneassociated protein 43 (GAP-43; a gene not regulated by REST) and of synapsin I and βIII tubulin (genes regulated by REST), proteins involved in the early stage of neuronal development. We observed that differentiation of SH-SY5Y cells by IGF-I and PMA was accompanied …