Global ETD Search
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Showing 1 to 6 of 6 for “"GADD45A"”.
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THE ROLE OF THE STRESS RESPONSE GENE GADD45A IN MODULATING MYC MEDIATED APOPTOSIS AND DIFFERENTIATION
… different stressors, including oncogenic stress. Gadd45a expression is regulated during myeloid cell differentiation, and is also induced in response to acute stimulation with cytokines, myeloablation and inflammation. The proto-oncogene C-myc plays a pivotal role in growth control, …
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… target, a stress-responsive gene named GADD45A, which serves as a regulator of HSC activation. Finally, we show that HSC-specific deletion of GADD45A limits CCl₄-driven fibrogenesis in vivo with reduced collagen deposition and limited HSC activation, likely through increased HSC …
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The Role of the Stress Response Gene Gadd45b in Senescence
The Gadd45 family of proteins (Gadd45a, Gadd45b, and Gadd45g) has been shown to act as stress sensors in response to various physiological and environmental stressors, including oncogenic stress. However, the role of Gadd45b in senescence remained unclear. Here, we show for the first time that …
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Strahleninduzierte Genexpression von Zellzykluskontroll- und DNA-Reparaturgenen als Biomarker für individuelle Strahlenempfindlichkeit
… von CDKN1A (p21, Cip1, WAF1), PCNA, TP53, XPC, GADD45A und DDB2 4h nach Bestrah¬lung in vitro bestimmt. Die erhaltenen Induktionswerte wurden mit dem Ausmaß der Neben¬wir¬kun¬gen ver¬glichen, die die Patienten während ihrer Bestrahlung tatsächlich entwickelten. Zum besseren Verständnis der im …
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Role of retinoblastoma protein in the development of liver cancer
… Analysis of the G2/M checkpoint proteins such as Gadd45a, MAD2 and CDC25a all show a dysregulation in their activities. In conclusion Rb loss leads to aberrant regulation of p53 and induces DNA damage, this superimposed on a background of a lack of cell cycle control predisposes the hepatocyte to …
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Transcriptomic and metagenomic impacts of dietary energy of milk replacer in pre-weaned Holstein heifers
… and cell proliferation (LD = 2, A = 3; i.e. GADD45A, CDKN1A). There was a difference in both the transcriptome and rumen microbiome of calves fed differing levels of dietary energy. The calves on the R diet had a rumen microbial composition more similar to a younger calf, while the …