Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"GAD65"”.
-
Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… in male nNOS-/- mice. Lastly, there is decreased GAD65/67 expression in both male and female nNOS-/- nice compared to age-matched WT mice. Our results provide new knowledge of NO regulation of cerebellar synaptic transmission, which may advance the development of cerebellar ataxia therapeutics.
-
Engineering Secreted Proteins for Gene Transfer and DNA Vaccination
… autoimmune disease using gene vaccination, human GAD65 was engineered to be secreted by mammalian cells. GAD65 is a major autoimmune antigen involved in the development of type I diabetes in both non-obese diabetic (NOD) mice and human patients. After the removal of the N-terminal end of GAD65, …
-
Effects of developmental PCB exposure on audiogenic and amygdala kindling models of seizure
… There also was a significant decrease in GAD65 but no decrease in GAD67 or GABAAα1 protein levels in the IC of PCB exposed animals compared to controls. A study was then conducted to assess whether developmental PCB exposure would result in increased seizure susceptibility outside the …
-
Molekularbiologische Untersuchungen zu zentralnervösen Alterungsprozessen der Reproduktionsfunktion in der weiblichen Ratte
… Gentranskripte der beiden Isoformen von GAD, GAD65 und GAD67, mittels der Methode der in situ Hybridisierung in der POA, im Nukleus suprachiasmaticus (SCN), im mediobasalen Hypothalamus (MBH) und im Gyrus dentatus bestimmt. In allen untersuchten Regionen konnte nach der Kastration und einer …
-
Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… its receptors, and glutamic acid decarboxylase (GAD65/67); its rate limiting enzyme. GABAergic interneurons function as essential regulators of fear memory through their direct inhibitory influence on excitatory pyramidal cells (PCs) throughout the amygdala, hippocampus, and PFC. This study …
-
The genetic background of gestational diabetes mellitus
… against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. The HLA-DQB1*0602 allele which is considered to be protective for type 1 diabetes had a negative association with GDM …
-
Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease
… neuronal substrates such as SNAP25, PSD95 and GAD65. By contrast, mutant htt does not act this way, probably due to lack of interaction with HIP14. Furthermore, immunoprecipitated HIP14 from huntingtin+/- mice also exhibits less enzyme activity in palmitoylating GST-SNAP25 in vitro, suggesting …
-
Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
… response against the beta cell antigen GAD65 between the groups. The slower progression of beta cell failure in LADA might be due to a more balanced T cell response that reduces the cytotoxic Thl cell mediated response. Type 1 diabetes and LADA could thus be considered as different …
-
Direct generation of region-specific induced neural Precursors from adult human fibroblasts using non-viral and viral methods
… assessed using neuronal markers NSE, VGLUT1, and GAD65/67 after differentiating in the neuronal media. Lentiviral-derived populations were further enriched by FACS, and NSE-positive neurons comprising either glutamatergic or GABAergic phenotypes were efficiently generated from SOX2/PAX6 and SOX2 …
-
Aspects of autoantibody epitopes in type 1 diabetes
… sequence variations are not found for insulin, GAD65 or IA-2. Neuropeptide Y (NPY) was reported as a minor autoantigen in T1D. This neurotransmitter has a SNP, rs16139, at aa position 7 in the NPY gene. The major allele is coding for leucine (L), and the minor for proline (P). The latter has …
-
ROLE OF CELLULAR STRESS RESPONSES IN THE PATHOPHYSIOLOGY AND TREATMENT OF PSYCHIATRIC DISORDERS
… explore this hypothesis, we stained slices with GAD65 (inhibitory interneurons marker) and Parvalbumin (marker of a specific subtype of inhibitory interneurons), confirming their partial involvement in the HO1-mediated antioxidant response. As we are aware that the complexity of the molecular …