Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"GABRA2"”.
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Effect of GABRA2 expression in the central nucleus of the amygdala on anxiety and alcohol's anxiolytic capacity in C57BL/6J mice
The GABRA2 gene, which encodes the α2 subunit of GABAA receptors, is one of the genes most frequently associated with alcohol-related behavior in human studies (Demers, Bogdan, & Agrawal, 2014). Polymorphisms in GABRA2 have been found to be associated with alcohol dependence, changes in drinking …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… in humans revealed a genetic association of GABRA2 haplotypes with cocaine addiction, which was evident only in individuals who had experienced childhood trauma. Collectively, these studies indicate an association of childhood trauma, drug addiction and the GABRA2 haplotype. Here, I have …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… in the gene of a subunit of GABA receptors - Gabra2 that reduces contextual fear memory in C57BL/6J by using quantitative trait locus analysis. In the third component (Chapter 4), I found a change in GABAB receptor-mediated feedforward inhibition led to distinct hippocampal responses to …
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Longitudinal Metabolic and Proteomic Changes Studied in an Experimental Model of Traumatic Brain Injury
… changes in glutamate transporter Slc1a2 and Gabra2 in the cortex, suggesting that the balance between glutamate and GABA is unresolved influx even 1 year post injury. At these later time points (> 2 weeks), interventions aimed at enhancing reparative processes like ApoE mimetics, or …